MGI phenotypes (allele matching)
- renal/urinary system phenotype / MGI
B6.Cg-Ddntm1Ktry/Kctt
| Status | Available to order |
| EMMA ID | EM:10416 |
| Citation information | RRID:IMSR_EM:10416 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ddntm1Ktry/Kctt |
| Alternative name | B6.129P-Ddn tm1Ktry |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ddntm1Ktry |
| Gene/Transgene symbol | Ddn |
Information from provider
| Provider | Karl Tryggvason |
| Provider affiliation | MBB, Karolinska Institutet |
| Genetic information | The coding sequence of exons 1 and 2, which represent the whole coding sequence of dendrin, were replaced with an eGFP-containing cassette (eGFP loxP-Ub1-EM7-Neo-loxP cassette). Thus, the genomic sequence of dendrin (position 99265856-99268375 bp in chromosome 15) from start codon ATG to the stop codon TGA was replaced, in frame with respect to the dendrin initiation codon, by the coding sequence of eGFP and a loxP flanked neomycin gene driven by a mammalian promoter. |
| Phenotypic information | Homozygous:renal/urinary system phenotypeHeterozygous:No abnormal phenotype detected |
| Breeding history | The mice were backcrossed more than 10 generations to C57BL/6N strain. Two generations ago the siblings were crossed together and the strain is maintained as full knockout. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
MGI phenotypes (gene matching)
- renal/urinary system phenotype / MGI
Literature references
- Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.;Xiao Zhijie, Rodriguez Patricia Q, He Liqun, Betsholtz Christer, Tryggvason Karl, Patrakka Jaakko, ;2013;PloS one;8;e83133; 24376653