STOCK Tubb5tm2.1Dak/Biat
| Status | Available to order |
| EMMA ID | EM:10543 |
| Citation information | RRID:IMSR_EM:10543 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tubb5tm2.1Dak/Biat |
| Alternative name | Tubb5 KO / Freddie |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tubb5tm2.1Dak |
| Gene/Transgene symbol | Tubb5 |
Information from provider
| Provider | David Keays |
| Provider affiliation | Keays Group, Institute of Molecular Pathology |
| Genetic information | The terminal exon of the Tubb5 gene (exon 4) was flanked with loxP sites. |
| Phenotypic information | Homozygous:When employing nestin promoter-driven cre recombinase, homozygous animals are not viable.Heterozygous:When employing nestin promoter-driven cre recombinase, heterozygous animals are presented with a large reduction in total brain as well as cortical volume. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6 males |
Literature references
- Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.;Breuss Martin, Fritz Tanja, Gstrein Thomas, Chan Kelvin, Ushakova Lyubov, Yu Nuo, Vonberg Frederick W, Werner Barbara, Elling Ulrich, Keays David A, ;2016;Development (Cambridge, England);143;1126-33; 26903504