STOCK Tg(Tubb5-EGFP)1Dak/Biat

Status	Available to order
EMMA ID	EM:10544
Citation information	RRID:IMSR_EM:10544 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Tg(Tubb5-EGFP)1Dak/Biat
Alternative name	Tubb5 GFP / Kermit
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Tubb5-EGFP)1Dak
Gene/Transgene symbol	Tg(Tubb5-EGFP)1Dak

Information from provider

Provider	David Keays
Provider affiliation	Keays Group, Institute of Molecular Pathology
Genetic information	A Bacterial Artificial Chromosome (BAC; RP24-330C1) containing the Tubb5 gene was genetically modified to contain enhanced green fluorescent protein (EGFP) in the Tubb5 locus.
Phenotypic information	Homozygous: Only heterozygous have been analysed so far. Heterozygous: The mouse line drives EGFP from the endogenous Tubb5 promoter to determine which cell types express Tubb5.
References	Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.;Breuss Martin, Heng Julian Ik-Tsen, Poirier Karine, Tian Guoling, Jaglin Xavier Hubert, Qu Zhengdong, Braun Andreas, Gstrein Thomas, Ngo Linh, Haas Matilda, Bahi-Buisson Nadia, Moutard Marie-Laure, Passemard Sandrine, Verloes Alain, Gressens Pierre, Xie Yunli, Robson Kathryn J H, Rani Deepa Selvi, Thangaraj Kumarasamy, Clausen Tim, Chelly Jamel, Cowan Nicholas Justin, Keays David Anthony, ;2012;Cell reports;2;1554-62; 23246003
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	yes

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6N males

Literature references

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.;Breuss Martin, Heng Julian Ik-Tsen, Poirier Karine, Tian Guoling, Jaglin Xavier Hubert, Qu Zhengdong, Braun Andreas, Gstrein Thomas, Ngo Linh, Haas Matilda, Bahi-Buisson Nadia, Moutard Marie-Laure, Passemard Sandrine, Verloes Alain, Gressens Pierre, Xie Yunli, Robson Kathryn J H, Rani Deepa Selvi, Thangaraj Kumarasamy, Clausen Tim, Chelly Jamel, Cowan Nicholas Justin, Keays David Anthony, ;2012;Cell reports;2;1554-62; 23246003

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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