B6.129P2-Dp(16Mir802-Zbtb21)3TybEmcf/TybH
| Status | Available to order |
| EMMA ID | EM:10559 |
| Citation information | RRID:IMSR_EM:10559 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Dp(16Mir802-Zbtb21)3TybEmcf/TybH |
| Alternative name | Dp3Tyb |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Dp(16Mir802-Zbtb21)3TybEmcf |
| Gene/Transgene symbol | Dp(16Mir802-Zbtb21)3TybEmcf |
Information from provider
| Provider | Victor Tybulewicz |
| Provider affiliation | Francis Crick Institute |
| Additional owner | Elizabeth Fisher, University College London, UK |
| Genetic information | Duplication of 4.9Mb of Mmu16 from Mir802 to Zbtb21 |
| Phenotypic information | Homozygous:UnknownHeterozygous:Congenital heart defects, locomotor dysfunction. |
| Breeding history | Mutation established in HM-1 ES cells, transmitted through germline and then backcrossed to C57BL/6J |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J males |
| Breeding at archiving centre | Backcrossed onto C57BL/6J |
Literature references
- Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.;Lana-Elola Eva, Watson-Scales Sheona, Slender Amy, Gibbins Dorota, Martineau Alexandrine, Douglas Charlotte, Mohun Timothy, Fisher Elizabeth Mc, Tybulewicz Victor Lj, ;2016;eLife;5;1165-1186; 26765563
- Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;eadd6883; 28993310
- Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.;Lana-Elola Eva, Aoidi Rifdat, Llorian Miriam, Gibbins Dorota, Buechsenschuetz Callan, Bussi Claudio, Flynn Helen, Gilmore Tegan, Watson-Scales Sheona, Haugsten Hansen Marie, Hayward Darryl, Song Ok-Ryul, Brault Véronique, Herault Yann, Deau Emmanuel, Meijer Laurent, Snijders Ambrosius P, Gutierrez Maximiliano G, Fisher Elizabeth M C, Tybulewicz Victor L J, ;2024;Science translational medicine;16;; 38266108