CD1.129-Adora2a^tm1Map/Cnbc

Status	Available to order
EMMA ID	EM:10582
Citation information	RRID:IMSR_EM:10582 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	CD1.129-Adora2a^tm1Map/Cnbc
Alternative name	A2a KO outbred
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Adora2a^tm1Map
Gene/Transgene symbol	Adora2a

Information from provider

Provider	Catherine LEDENT
Provider affiliation	IRIBHM - Faculté de Médecine, Université Libre de Bruxelles
Genetic information	Adenosine A2A receptor knockout.
Phenotypic information	Homozygous: Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor, C. Ledent, J-M. Vaugeois, S. Schiffmann, T. Pedrazzini, M. EL Yacoubi, J.-J. Vanderhaegen, J. Costentin, J. K. Heath, G. Vassart and M. Parmentier, Nature (1997) 388, 674-678. Heterozygous: no phenotype
Breeding history	Backcross CD1: HE x CD1 WT ; HE x CD1 WT .... (N >20)
References	Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.;Ledent C, Vaugeois J M, Schiffmann S N, Pedrazzini T, El Yacoubi M, Vanderhaeghen J J, Costentin J, Heath J K, Vassart G, Parmentier M, ;1997;Nature;388;674-8; 9262401
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) males, wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) females
Stage of embryos	2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)

increased total body fat amount / IMPC
increased circulating alanine transaminase level / IMPC
decreased hemoglobin content / IMPC
decreased lean body mass / IMPC
increased circulating glucose level / IMPC
decreased lymphocyte cell number / IMPC
decreased locomotor activity / IMPC
increased circulating aspartate transaminase level / IMPC
increased neutrophil cell number / IMPC
increased freezing behavior / IMPC

MGI phenotypes (allele matching)

decreased interleukin-10 secretion / MGI
increased aggression towards males / MGI
increased anxiety-related response / MGI
decreased exploration in new environment / MGI
abnormal liquid preference / MGI
abnormal cardiovascular system physiology / MGI
increased thermal nociceptive threshold / MGI
increased heart rate / MGI
increased systemic arterial blood pressure / MGI
hypoalgesia / MGI
abnormal locomotor activation / MGI
increased body mass index / MGI
increased platelet aggregation / MGI
impaired behavioral response to alcohol / MGI

MGI phenotypes (gene matching)

heart right ventricle hypertrophy / MGI
abnormal pulmonary artery morphology / MGI
increased aggression towards males / MGI
increased anxiety-related response / MGI
hypoactivity / MGI
decreased exploration in new environment / MGI
abnormal liquid preference / MGI
abnormal cardiovascular system physiology / MGI
increased thermal nociceptive threshold / MGI
increased heart rate / MGI
abnormal sclera morphology / MGI
increased systemic arterial blood pressure / MGI
vascular smooth muscle hypertrophy / MGI
hypoalgesia / MGI
myopia / MGI
abnormal locomotor activation / MGI
pulmonary hypertension / MGI
nervous system phenotype / MGI
abnormal lung vasculature morphology / MGI
cardiovascular system phenotype / MGI
vision/eye phenotype / MGI
decreased cerebral infarction size / MGI
decreased susceptibility to ischemic brain injury / MGI
increased body mass index / MGI
decreased interleukin-10 secretion / MGI
decreased physiological sensitivity to xenobiotic / MGI
increased platelet aggregation / MGI
impaired behavioral response to addictive substance / MGI
impaired behavioral response to alcohol / MGI
increased right ventricle systolic pressure / MGI

Literature references

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.;Ledent C, Vaugeois J M, Schiffmann S N, Pedrazzini T, El Yacoubi M, Vanderhaeghen J J, Costentin J, Heath J K, Vassart G, Parmentier M, ;1997;Nature;388;674-8; 9262401

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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CD1.129-Adora2atm1Map/Cnbc