IMPC phenotypes (gene matching)
CD1.129-Cnr1tm1Map/Cnbc
| Status | Available to order |
| EMMA ID | EM:10583 |
| Citation information | RRID:IMSR_EM:10583 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CD1.129-Cnr1tm1Map/Cnbc |
| Alternative name | CB1 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cnr1tm1Map |
| Gene/Transgene symbol | Cnr1 |
Information from provider
| Provider | Catherine LEDENT |
| Provider affiliation | IRIBHM - Faculté de Médecine, Université Libre de Bruxelles |
| Genetic information | Cannabinoid receptor type 1 knockout. |
| Phenotypic information | Homozygous:Unresponsiveness to Cannabinoids and Reduced Addictive Effects Of Opiates in CB1 Receptor Knock Out Mice, C. Ledent, O. Valverde, G. Cossu, F. Petitet, J.-F. Aubert, F. Beslot, A. Böhme, A. Imperato, T. Pedrazzini, B.P. Roques, G. Vassart, W. Fratta, M. Parmentier, Science (1999) 283, 401-404.Heterozygous:no phenotype |
| Breeding history | Backcrosses: HE x WT ; HE x WT ... more than 20x |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) males, wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased cerebral infarction size / MGI
- abnormal nervous system physiology / MGI
- abnormal sweet taste sensitivity / MGI
- increased bone mineral density / MGI
- abnormal sperm motility / MGI
- abnormal inhibitory postsynaptic currents / MGI
- enhanced long term potentiation / MGI
- skeleton phenotype / MGI
- abnormal bone mineral density / MGI
- increased aggression towards mice / MGI
- increased anxiety-related response / MGI
- hyperactivity / MGI
- increased exploration in new environment / MGI
- increased circulating adrenocorticotropin level / MGI
- decreased chemically-elicited antinociception / MGI
- abnormal social/conspecific interaction / MGI
- abnormal active avoidance behavior / MGI
- increased susceptibility to ischemic brain injury / MGI
- abnormal depression-related behavior / MGI
- abnormal response to novel object / MGI
- abnormal neuronal precursor proliferation / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- increased physiological sensitivity to xenobiotic / MGI
- anhedonia / MGI
- impaired conditioned place preference behavior / MGI
- impaired behavioral response to addictive substance / MGI
- impaired behavioral response to morphine / MGI
- increased sensitivity to induced morbidity/mortality / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal cerebral cortex morphology / MGI
- decreased body weight / MGI
- weight loss / MGI
- increased aggression towards mice / MGI
- increased anxiety-related response / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- increased exploration in new environment / MGI
- decreased exploration in new environment / MGI
- abnormal cued conditioning behavior / MGI
- reduced long term depression / MGI
- increased circulating corticosterone level / MGI
- increased circulating adrenocorticotropin level / MGI
- absent long term depression / MGI
- increased thermal nociceptive threshold / MGI
- increased chemically-elicited antinociception / MGI
- decreased chemically-elicited antinociception / MGI
- abnormal learning/memory/conditioning / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal social/conspecific interaction / MGI
- abnormal sperm motility / MGI
- decreased circulating insulin level / MGI
- decreased vertical activity / MGI
- abnormal active avoidance behavior / MGI
- catalepsy / MGI
- increased insulin sensitivity / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased synaptic depression / MGI
- abnormal paired-pulse facilitation / MGI
- abnormal inhibitory postsynaptic currents / MGI
- enhanced long term potentiation / MGI
- no phenotypic analysis / MGI
- hypoalgesia / MGI
- increased susceptibility to ischemic brain injury / MGI
- abnormal depression-related behavior / MGI
- abnormal response to novel object / MGI
- nervous system phenotype / MGI
- abnormal nervous system morphology / MGI
- abnormal nervous system physiology / MGI
- maternal effect / MGI
- abnormal nervous system development / MGI
- abnormal sweet taste sensitivity / MGI
- abnormal neuron physiology / MGI
- abnormal synaptic plasticity / MGI
- abnormal neuronal precursor proliferation / MGI
- increased follicle stimulating hormone level / MGI
- increased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- behavior/neurological phenotype / MGI
- skeleton phenotype / MGI
- abnormal food intake / MGI
- decreased percent body fat/body weight / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- increased cerebral infarction size / MGI
- increased susceptibility to neuronal excitotoxicity / MGI
- increased chemical nociceptive threshold / MGI
- decreased survivor rate / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal axon fasciculation / MGI
- impaired cued conditioning behavior / MGI
- anhedonia / MGI
- impaired conditioned place preference behavior / MGI
- impaired behavioral response to xenobiotic / MGI
- impaired behavioral response to addictive substance / MGI
- impaired behavioral response to morphine / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased behavioral withdrawal response / MGI
- decreased total body fat amount / MGI
- abnormal bone mineral density / MGI
- postnatal lethality, incomplete penetrance / MGI
- early parturition / MGI
Literature references
- Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.;Ledent C, Valverde O, Cossu G, Petitet F, Aubert J F, Beslot F, Böhme G A, Imperato A, Pedrazzini T, Roques B P, Vassart G, Fratta W, Parmentier M, ;1999;Science (New York, N.Y.);283;401-4; 9888857