MGI phenotypes (allele matching)
B6.Cg-Tie1tm1Jpa/Oulu
| Status | Available to order |
| EMMA ID | EM:10789 |
| Citation information | RRID:IMSR_EM:10789 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tie1tm1Jpa/Oulu |
| Alternative name | Tie1/LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tie1tm1Jpa |
| Gene/Transgene symbol | Tie1 |
Information from provider
| Provider | Juha Partanen |
| Provider affiliation | Department of Biosciences, University of Helsinki |
| Genetic information | A lacZ gene followed by a loxP-flanked neomycin selection cassette replaced coding sequences in the first coding exon such that the lacZ gene was expressed under the control of the endogenous promoter. |
| Phenotypic information | Homozygous:Homozygous mice are embryonic lethal around E14.Heterozygous:No obvious phenotype. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal small intestine morphology / MGI
- thick pulmonary interalveolar septum / MGI
- edema / MGI
- skin edema / MGI
- abnormal lymphatic vessel morphology / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- postnatal lethality / MGI
- no abnormal phenotype detected / MGI
- small heart / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal heart atrium morphology / MGI
- abnormal vascular branching morphogenesis / MGI
- intestinal edema / MGI
- abnormal vascular endothelial cell development / MGI
- abnormal lymph circulation / MGI
- pulmonary edema / MGI
- abnormal endocardium morphology / MGI
- lymphatic vessel hyperplasia / MGI
- dilated vasculature / MGI
- abnormal renal glomerulus morphology / MGI
- cardiovascular system phenotype / MGI
- abnormal vascular endothelial cell morphology / MGI
- abnormal lymphangiogenesis / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
Literature references
- The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.;Puri M C, Rossant J, Alitalo K, Bernstein A, Partanen J, ;1995;The EMBO journal;14;5884-91; 8846781