B6.Cg-Tg(Thy1-SERPINI1)682Zbz/Biat

Status	Available to order
EMMA ID	EM:10870
Citation information	RRID:IMSR_EM:10870 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(Thy1-SERPINI1)682Zbz/Biat
Alternative name	Tg(NS)682Zbz
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Thy1-SERPINI1)682Zbz
Gene/Transgene symbol	Tg(Thy1-SERPINI1)682Zbz

Information from provider

Provider	Thomas Ruelicke
Provider affiliation	Department 1 (Biomedical Sciences), University of Veterinary Medicine, Vienna
Genetic information	Transgenic mice overexpressing wild-type human neuroserpin under the control of the Thy1 promoter were generated by pronuclear injection into fertilized oocytes using an expression cassette derived from the murine Thy1 gene. The transgene was expressed in central nervous system neurons throughout postnatal life. The expression levels for transgenic mice overexpressing human Syracuse neuroserpin were for transgenic mice with human wild-type neuroserpin 5.9 times above the endogenous neuroserpin level of wild-type mice.
Phenotypic information	Homozygous: unknown Heterozygous: Control mice for Tg(NS)680Zbz. The expression levels for transgenic mice overexpressing human Syracuse neuroserpin were for transgenic mice with human wild-type neuroserpin 3.4 times above the endogenous neuroserpin level of wild-type mice.
Breeding history	The transgenic lines were generated on a B6D2F2 hybrid background and backcrossed to C57BL/6J for at least 10 generations.
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6J males

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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Practical information

Example health report
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