IMPC phenotypes (gene matching)
B6.129(Cg)-Ftotm1.1Rdc/H
| Status | Available to order |
| EMMA ID | EM:10891 |
| Citation information | RRID:IMSR_EM:10891 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129(Cg)-Ftotm1.1Rdc/H |
| Alternative name | C57BL/6J.129-Fto |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ftotm1.1Rdc |
| Gene/Transgene symbol | Fto |
Information from provider
| Provider | Simon T Ball |
| Provider affiliation | MRC Harwell |
| Genetic information | LoxP-Exon3-FRT-PgkNeo-FRT-LoxP construct inserted by homologous recombination into FTO exon 3. The neomycin resistance cassette was removed via flp-mediated recombination and left exon 3 floxed |
| Phenotypic information | Homozygous:No known phenotype.Heterozygous:No known phenotype. |
| Breeding history | Targeted mutation on R1 ES cell line. Resulting chimaera mated to C57BL/6J, then crossed to Actin FLPE to remove the PgkNeo cassette. Strain then maintained by crossing to C57BL/6J for nine generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Lethal polymalformative syndrome, Boissel type / Orphanet_210144
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- decreased circulating LDL cholesterol level / MGI
- dermatitis / MGI
- decreased body length / MGI
- decreased body weight / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- abnormal eating behavior / MGI
- polyphagia / MGI
- increased circulating triglyceride level / MGI
- increased circulating HDL cholesterol level / MGI
- postnatal growth retardation / MGI
- increased circulating glucagon level / MGI
- decreased circulating insulin level / MGI
- decreased circulating alanine transaminase level / MGI
- increased lean body mass / MGI
- decreased lean body mass / MGI
- decreased circulating iron level / MGI
- decreased circulating insulin-like growth factor I level / MGI
- increased energy expenditure / MGI
- cachexia / MGI
- increased circulating cholesterol level / MGI
- abnormal metabolism / MGI
- abnormal oxygen consumption / MGI
- increased oxygen consumption / MGI
- improved glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- abnormal circulating hormone level / MGI
- decreased percent body fat/body weight / MGI
- increased circulating glucose level / MGI
- decreased lactate dehydrogenase level / MGI
- decreased circulating aspartate transaminase level / MGI
- increased susceptibility to diet-induced obesity / MGI
- decreased susceptibility to diet-induced obesity / MGI
- increased circulating adrenaline level / MGI
- decreased circulating leptin level / MGI
- increased circulating leptin level / MGI
- abnormal carbon dioxide production / MGI
- increased carbon dioxide production / MGI
- decreased carbon dioxide production / MGI
- increased basal metabolism / MGI
- decreased white fat cell size / MGI
- decreased gonadal fat pad weight / MGI
- increased total body fat amount / MGI
- decreased total body fat amount / MGI
- increased respiratory quotient / MGI
- decreased respiratory quotient / MGI
- postnatal lethality, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal urine catecholamine level / MGI
- increased food intake / MGI
Literature references
- Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.;McMurray Fiona, Church Chris D, Larder Rachel, Nicholson George, Wells Sara, Teboul Lydia, Tung Y C Loraine, Rimmington Debra, Bosch Fatima, Jimenez Veronica, Yeo Giles S H, O'Rahilly Stephen, Ashcroft Frances M, Coll Anthony P, Cox Roger D, ;2013;PLoS genetics;9;e1003166; 23300482