B6.Cg-Tg(Col6a1-TNFRSF1/GH1)1Gkl/Flmg

Status	Available to order
EMMA ID	EM:10895
Citation information	RRID:IMSR_EM:10895 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(Col6a1-TNFRSF1/GH1)1Gkl/Flmg
Alternative name	TgC6HP55 [B6-Tg(Col6a1-TNFRSF1/GH1)1Gkl/Flmg]
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Col6a1-TNFRSF1/GH1)1Gkl
Gene/Transgene symbol	Tg(Col6a1-TNFRSF1/GH1)1Gkl

Information from provider

Provider	George Kollias
Provider affiliation	BSRC Fleming
Genetic information	The transgene contains a 1.5 kb fragment encompassing the human TNFR1 coding DNA sequence, downstream of the 7.5 kb 5’-flanking region of the mouse collagen, type VI, alpha 1 promoter, followed by a 2.1 kb human GH1 minigene. The transgenic line carries 2 copies of the transgene.
Phenotypic information	Homozygous: Unknown Heterozygous: Transgenic mice exhibit growth enhancement.
References	Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.;Kaklamanos Aimilios, Rozman Jan, Roulis Manolis, Karagianni Niki, Armaka Maria, Wu Moya, Brachthäuser Laura, Calzada-Wack Julia, Horsch Marion, Beckers Johannes, Rathkolb Birgit, Adler Thure, Neff Frauke, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabe, Kollias George, ;2017;Scientific reports;7;2397; 28546545
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	B.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archiving	heterozygous C57BL/6J males

Literature references

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.;Kaklamanos Aimilios, Rozman Jan, Roulis Manolis, Karagianni Niki, Armaka Maria, Wu Moya, Brachthäuser Laura, Calzada-Wack Julia, Horsch Marion, Beckers Johannes, Rathkolb Birgit, Adler Thure, Neff Frauke, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabe, Kollias George, ;2017;Scientific reports;7;2397; 28546545

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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