- abnormal placenta morphology / IMPC
- abnormal craniofacial morphology / IMPC
- abnormal facial morphology / IMPC
- abnormal placenta size / IMPC
- preweaning lethality, complete penetrance / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- hemorrhage / IMPC
- microphthalmia / IMPC
- embryonic growth retardation / IMPC
- abnormal head shape / IMPC
- edema / IMPC
129.B6-Hmox1tm1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:10935 |
| Citation information | RRID:IMSR_EM:10935 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129.B6-Hmox1tm1Gkl/Flmg |
| Alternative name | 129.B6-Hmox1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Hmox1tm1Gkl |
| Gene/Transgene symbol | Hmox1 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Fleming |
| Genetic information | Mice contain loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 surrounding exons 3 to 4 of the mouse Hmox1 gene. |
| Phenotypic information | Homozygous:No overt pathology.Heterozygous:No overt pathology. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous 129P2/OlaHsd x C57BL/6 males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Heme oxygenase-1 deficiency / Orphanet_562509
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- abnormal leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- altered response to myocardial infarction / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- small testis / MGI
- decreased body size / MGI
- hypoactivity / MGI
- poor grooming / MGI
- abnormal cardiovascular system physiology / MGI
- increased inflammatory response / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- infertility / MGI
- premature death / MGI
- abnormal artery morphology / MGI
- chronic inflammation / MGI
- decreased mean corpuscular volume / MGI
- anisocytosis / MGI
- glomerulonephritis / MGI
- dilated heart right ventricle / MGI
- microcytic anemia / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- increased circulating alanine transaminase level / MGI
- abnormal cardiac muscle contractility / MGI
- increased myocardial infarction size / MGI
- cardiac fibrosis / MGI
- increased cardiomyocyte apoptosis / MGI
- liver failure / MGI
- liver fibrosis / MGI
- kidney failure / MGI
- oxidative stress / MGI
- increased heart right ventricle weight / MGI
- decreased circulating iron level / MGI
- increased renal tubule apoptosis / MGI
- renal tubular necrosis / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal thrombosis / MGI
- cachexia / MGI
- glomerulosclerosis / MGI
- increased blood urea nitrogen level / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal iron homeostasis / MGI
- myocardial necrosis / MGI
- abnormal splenic cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- increased susceptibility to parasitic infection induced morbidity/mortality / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- proximal convoluted tubule brush border loss / MGI
- renal cast / MGI
- glomerular crescent / MGI
- cerebral edema / MGI
- increased circulating ferritin level / MGI
Literature references
- Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.;Tzima Sotiria, Victoratos Panayiotis, Kranidioti Ksanthi, Alexiou Maria, Kollias George, ;2009;The Journal of experimental medicine;206;1167-79; 19398754
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