129.B6-Hmox1tm1Gkl/Flmg

Status

Available to order

EMMA IDEM:10935
Citation informationRRID:IMSR_EM:10935 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain name129.B6-Hmox1tm1Gkl/Flmg
Alternative name129.B6-Hmox1/Flmg
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolHmox1tm1Gkl
Gene/Transgene symbolHmox1

Information from provider

ProviderGeorge Kollias
Provider affiliationBSRC Fleming
Genetic informationMice contain loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 surrounding exons 3 to 4 of the mouse Hmox1 gene.
Phenotypic informationHomozygous:
No overt pathology.

Heterozygous:
No overt pathology.
References
  • Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.;Tzima Sotiria, Victoratos Panayiotis, Kranidioti Ksanthi, Alexiou Maria, Kollias George, ;2009;The Journal of experimental medicine;206;1167-79; 19398754
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivinghomozygous 129P2/OlaHsd x C57BL/6 males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal placenta morphology / IMPC
  • abnormal craniofacial morphology / IMPC
  • abnormal facial morphology / IMPC
  • abnormal placenta size / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • hemorrhage / IMPC
  • microphthalmia / IMPC
  • embryonic growth retardation / IMPC
  • abnormal head shape / IMPC
  • edema / IMPC
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal leukocyte cell number / MGI
  • extramedullary hematopoiesis / MGI
  • altered response to myocardial infarction / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • enlarged lymph nodes / MGI
  • small testis / MGI
  • decreased body size / MGI
  • hypoactivity / MGI
  • poor grooming / MGI
  • abnormal cardiovascular system physiology / MGI
  • increased inflammatory response / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • infertility / MGI
  • premature death / MGI
  • abnormal artery morphology / MGI
  • chronic inflammation / MGI
  • decreased mean corpuscular volume / MGI
  • anisocytosis / MGI
  • glomerulonephritis / MGI
  • dilated heart right ventricle / MGI
  • microcytic anemia / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • increased circulating alanine transaminase level / MGI
  • abnormal cardiac muscle contractility / MGI
  • increased myocardial infarction size / MGI
  • cardiac fibrosis / MGI
  • increased cardiomyocyte apoptosis / MGI
  • liver failure / MGI
  • liver fibrosis / MGI
  • kidney failure / MGI
  • oxidative stress / MGI
  • increased heart right ventricle weight / MGI
  • decreased circulating iron level / MGI
  • increased renal tubule apoptosis / MGI
  • renal tubular necrosis / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal thrombosis / MGI
  • cachexia / MGI
  • glomerulosclerosis / MGI
  • increased blood urea nitrogen level / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • abnormal iron homeostasis / MGI
  • myocardial necrosis / MGI
  • abnormal splenic cell ratio / MGI
  • abnormal lymph node cell ratio / MGI
  • increased susceptibility to parasitic infection induced morbidity/mortality / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • proximal convoluted tubule brush border loss / MGI
  • renal cast / MGI
  • glomerular crescent / MGI
  • cerebral edema / MGI
  • increased circulating ferritin level / MGI

Literature references

  • Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.;Tzima Sotiria, Victoratos Panayiotis, Kranidioti Ksanthi, Alexiou Maria, Kollias George, ;2009;The Journal of experimental medicine;206;1167-79; 19398754

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).