- abnormal bone structure / IMPC
- increased circulating glucose level / IMPC
- abnormal optic disk morphology / IMPC
- abnormal clavicle morphology / IMPC
- abnormal joint morphology / IMPC
- increased large unstained cell number / IMPC
- increased eosinophil cell number / IMPC
- increased leukocyte cell number / IMPC
B6;129-Mapkapk2tm1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:10944 |
| Citation information | RRID:IMSR_EM:10944 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Mapkapk2tm1Gkl/Flmg |
| Alternative name | MK2FLneo/FLneo [129.B6-MapkapK2tm1Gkl/Flmg] |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mapkapk2tm1Gkl |
| Gene/Transgene symbol | Mapkapk2 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Fleming |
| Genetic information | MK2FLneo mice contain loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 flanking the area between exons 2-5 of the mouse Mapkapk2 gene. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6 males |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- altered response to myocardial infarction / MGI
- impaired macrophage phagocytosis / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal cytokine secretion / MGI
- decreased myocardial infarction size / MGI
- decreased cardiomyocyte apoptosis / MGI
- abnormal macrophage derived foam cell morphology / MGI
- increased spleen germinal center size / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased interleukin-1 beta secretion / MGI
- abnormal cytokine level / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
Literature references
- Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis.;Henriques Ana, Koliaraki Vasiliki, Kollias George, ;2018;Proceedings of the National Academy of Sciences of the United States of America;115;E5546-E5555; 29844172
Information on how we integrate external resources can be found here
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