MGI phenotypes (allele matching)
B6.129X1-Pxmp2tm1Jkh/Oulu
| Status | Available to order |
| EMMA ID | EM:10964 |
| Citation information | RRID:IMSR_EM:10964 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129X1-Pxmp2tm1Jkh/Oulu |
| Alternative name | Pxmp2tm1Jkh |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pxmp2tm1Jkh |
| Gene/Transgene symbol | Pxmp2 |
Information from provider
| Provider | Kalervo Hiltunen |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine, University of Oulu |
| Genetic information | A lacZ cassette and neo cassette in inverse orientation were inserted into exon 2 via homologous recombination. Northern blot and quantitative RT-PCR confirmed the absence of RNA expression. Immunoblot analysis confirmed the absence of protein expression in livers from homozygous mice. |
| Phenotypic information | Homozygous:These mice are viable, grow and breed normally. However, Pxmp2(-/-) female mice are unable to nurse their pups. Lactating mammary gland epithelium displays secretory lipid droplets and milk proteins, but the size of the ductal system is greatly reduced.Heterozygous:normal |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
Disease and phenotype information
Literature references
- Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane.;Rokka Aare, Antonenkov Vasily D, Soininen Raija, Immonen Hanna L, Pirilä Päivi L, Bergmann Ulrich, Sormunen Raija T, Weckström Matti, Benz Roland, Hiltunen J Kalervo, ;2009;PloS one;4;e5090; 19352492
- Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.;Vapola Miia H, Rokka Aare, Sormunen Raija T, Alhonen Leena, Schmitz Werner, Conzelmann Ernst, Wärri Anni, Grunau Silke, Antonenkov Vasily D, Hiltunen J Kalervo, ;2014;Developmental biology;391;66-80; 24726525