IMPC phenotypes (gene matching)
B6.Cg-Cyldtm1.2Gmos/Flmg
| Status | Available to order |
| EMMA ID | EM:10968 |
| Citation information | RRID:IMSR_EM:10968 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Cyldtm1.2Gmos/Flmg |
| Alternative name | B6-Cyld |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cyldtm1.2Gmos |
| Gene/Transgene symbol | Cyld |
Information from provider
| Provider | George Mosialos |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | Germ line, cre mediated recombination removed the neomycin cassette upstream of exon 9. Exon 9 of the mouse Cyld gene is flanked by loxP sites. This exon codes for an essential catalytic motif of the deubiquitination domain. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype |
| Breeding history | Backcrossed to C57BL/6 for at least 10 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 males, wild-type C57BL/6J females |
| Stage of embryos | Morula |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial cylindromatosis / Orphanet_211
- Familial multiple trichoepithelioma / Orphanet_867
MGI phenotypes (gene matching)
- abnormal circulating serum albumin level / MGI
- increased cell proliferation / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal colon morphology / MGI
- kinked tail / MGI
- short tail / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- thymus hyperplasia / MGI
- abnormal lung development / MGI
- atelectasis / MGI
- epidermal hyperplasia / MGI
- weight loss / MGI
- hunched posture / MGI
- cyanosis / MGI
- abnormal humoral immune response / MGI
- decreased IgM level / MGI
- abnormal inflammatory response / MGI
- increased skin papilloma incidence / MGI
- premature death / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal lung interstitium morphology / MGI
- abnormal respiratory function / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal B cell physiology / MGI
- increased IgA level / MGI
- gastric ulcer / MGI
- small lung / MGI
- increased incidence of tumors by chemical induction / MGI
- abnormal class switch recombination / MGI
- abnormal B cell morphology / MGI
- decreased B-1 B cell number / MGI
- increased B cell number / MGI
- increased double-positive T cell number / MGI
- immune system phenotype / MGI
- abnormal enzyme/coenzyme activity / MGI
- abnormal T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- enlarged Peyer's patches / MGI
- increased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased immature B cell number / MGI
- decreased IgG3 level / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- increased susceptibility to induced colitis / MGI
- abnormal keratinocyte proliferation / MGI
- increased keratinocyte proliferation / MGI
- decreased birth body size / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- neonatal lethality, complete penetrance / MGI
- thick lung-associated mesenchyme / MGI
- impaired fibroblast cell migration / MGI
Literature references
- Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation.;Trompouki Eirini, Tsagaratou Ageliki, Kosmidis Stylianos K, Dollé Pascal, Qian Jun, Kontoyiannis Dimitris L, Cardoso Wellington V, Mosialos George, ;2009;Neoplasia (New York, N.Y.);11;469-76; 19412431