B6.Cg-Tg(Tcra1H3.1,Tcrb1H3.1)1Vire/Orl

Status	Available to order
EMMA ID	EM:01097
Citation information	RRID:IMSR_EM:01097 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(Tcra1H3.1,Tcrb1H3.1)1Vire/Orl
Alternative name	1H3.1 alpha/beta (ab) T Cell Receptor (TCR) Transgenic (Tg) line. (common name: 1H3.1 TCR Tg)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Tcra1H3.1,Tcrb1H3.1)1Vire
Gene/Transgene symbol	Tg(Tcra1H3.1,Tcrb1H3.1)1Vire

Information from provider

Provider	Christophe Viret
Provider affiliation	INSERM U1111 - CNRS UMR5308, Centre International de Recherche en Infectiologie (CIRI)
Genetic information	Rearranged genes coding for the alpha and beta chains of the mouse 1H3.1 T cell receptor (TCR). Alpha chain: Va1-Ja21 segment combination. Beta Chain: Vb6-Db2.1-Jb2.6 segment combination. TCR specificity: Ea52-68:I-Ab complex. That is, the conserved 52 to 68 region of the mouse major histocompatibility complex (MHC) class II I-E alpha (I-Ea) chain recognized in the context of the mouse MHC class II I-Ab ab.
Phenotypic information	No defect known.
Breeding history	Backcrossed to C57BL/6 mice from Jackson more than 10 times, imported to Charles Rivers France, rederived on C57BL/6 background, currently bred and cryopreserved (embryos) at Charles Rivers France. The cryopreserved embryos could be directly imported to EMMA. There is no need to re-perform cryopreservation.
References	Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.;Viret C, Janeway C A, ;2000;Journal of immunology (Baltimore, Md. : 1950);164;4627-34; 10779766

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous males, wild-type C57BL/6J females

Literature references

Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.;Viret C, Janeway C A, ;2000;Journal of immunology (Baltimore, Md. : 1950);164;4627-34; 10779766

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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