B6(Cg)-Hspg2tm3.1Soin/Oulu

Status

Available to order

EMMA IDEM:10974
Citation informationRRID:IMSR_EM:10974 

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International strain nameB6(Cg)-Hspg2tm3.1Soin/Oulu
Alternative namePerlecan delta91
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolHspg2tm3.1Soin
Gene/Transgene symbolHspg2

Information from provider

ProviderRaija Soininen
Provider affiliationBiocenter Oulu, University of Oulu
Additional ownerDr Harri Elamaa, University of Oulu, Oulu, Finland
Genetic informationExon 91 of the perlecan (heparan sulfate proteoglycan 2) gene was first replaced by a loxP-flanked neo cassette by homologous recombination. The cassette was then removed by breeding with a mouse expressing the cre recombinase. Since the reading frame is not altered by the deletion, a protein lacking 19 amino acids is produced. The deletion leads to loss of the C-terminal glycosaminoglycan attachment site.
Phenotypic informationHomozygous:
Minor alterations in the lens capsule. Considerable weight increase (up to 50 g in old mice) especially in females, starting at 6 weeks of age in C57BL/6JOlaHsd background. However, normal weight in C57BL/6N background.

Heterozygous:
normal
Breeding historyChimeras generated by injection of C57BL/6N ES cells were bred with C57BL/6JOlaHsd mice for a few generations and then with C57BL/6NCrl mice.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal middle ear morphology / MGI
  • delayed bone ossification / MGI
  • abnormal bone marrow cavity morphology / MGI
  • absent neurocranium / MGI
  • short mandible / MGI
  • abnormal ethmoid bone morphology / MGI
  • abnormal sphenoid bone morphology / MGI
  • cleft palate / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal long bone epiphysis morphology / MGI
  • abnormal long bone metaphysis morphology / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal rib morphology / MGI
  • abnormal sternum morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cartilage development / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • abnormal chondrocyte morphology / MGI
  • abnormal pericardium morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal cranium morphology / MGI
  • domed cranium / MGI
  • short snout / MGI
  • short limbs / MGI
  • abnormal forelimb morphology / MGI
  • abnormal hindlimb morphology / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal telencephalon morphology / MGI
  • exencephaly / MGI
  • demyelination / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • lung hemorrhage / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • delayed eyelid opening / MGI
  • microphthalmia / MGI
  • abnormal gait / MGI
  • irregular heartbeat / MGI
  • decreased embryo size / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • respiratory failure / MGI
  • premature death / MGI
  • abnormal muscle morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal bone marrow morphology / MGI
  • disproportionate dwarf / MGI
  • chondrodystrophy / MGI
  • abnormal semilunar valve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal pulmonary valve morphology / MGI
  • abnormal endplate potential / MGI
  • abnormal joint morphology / MGI
  • impaired basement membrane formation / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • short femur / MGI
  • aneurysm / MGI
  • abnormal locomotor coordination / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • osteoarthritis / MGI
  • abnormal nervous system morphology / MGI
  • abnormal long bone epiphyseal plate proliferative zone / MGI
  • abnormal long bone morphology / MGI
  • abnormal bone structure / MGI
  • abnormal myelin sheath morphology / MGI
  • abnormal myocardium compact layer morphology / MGI
  • transposition of great arteries / MGI
  • abnormal chest morphology / MGI
  • abnormal muscle electrophysiology / MGI
  • increased compact bone thickness / MGI
  • abnormal spine curvature / MGI
  • abnormal basement membrane morphology / MGI
  • bowed humerus / MGI
  • absent frontal bone / MGI
  • absent parietal bone / MGI
  • short nasal bone / MGI
  • abnormal pelvic girdle bone morphology / MGI
  • enlarged vertebral body / MGI
  • decreased length of long bones / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal cardinal vein morphology / MGI
  • abnormal miniature endplate potential / MGI
  • abnormal behavior / MGI
  • abnormal osteoclast morphology / MGI
  • increased osteoclast cell number / MGI
  • abnormal intervertebral disk development / MGI
  • hemopericardium / MGI
  • abnormal occipital bone morphology / MGI
  • abnormal humerus morphology / MGI
  • abnormal myocardium layer morphology / MGI
  • homeostasis/metabolism phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal action potential / MGI
  • abnormal axon morphology / MGI
  • abnormal skeleton morphology / MGI
  • abnormal cell physiology / MGI
  • abnormal cardiac outflow tract development / MGI
  • disorganized long bone epiphyseal plate / MGI
  • increased diameter of long bones / MGI
  • increased diameter of humerus / MGI
  • abnormal bone ossification / MGI
  • abnormal endochondral bone ossification / MGI
  • decreased cranium height / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • skeletal muscle hyperplasia / MGI
  • abnormal heart and great artery attachment / MGI
  • abnormal ascending aorta and coronary artery attachment / MGI
  • abnormal conotruncus septation / MGI
  • absent conotruncal ridges / MGI
  • conotruncal ridge hyperplasia / MGI
  • abnormal node of Ranvier morphology / MGI
  • abnormal paranode morphology / MGI
  • abnormal internode morphology / MGI
  • increased Schwann cell number / MGI
  • mortality/aging / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • skin hemorrhage / MGI
  • flat face / MGI
  • decreased chondrocyte proliferation / MGI
  • decreased bone mineralization / MGI
  • abnormal radial glial cell endfoot morphology / MGI
  • wide cranial sutures / MGI
  • abnormal femur head morphology / MGI
  • abnormal femur neck morphology / MGI
  • short femur neck / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Genotyping protocol

Example health report
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