IMPC phenotypes (gene matching)
C57BL/6-Il1r1tm1.1Wme/Flmg
| Status | Available to order |
| EMMA ID | EM:10980 |
| Citation information | RRID:IMSR_EM:10980 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Il1r1tm1.1Wme/Flmg |
| Alternative name | B6-Il1r1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Il1r1tm1.1Wme |
| Gene/Transgene symbol | Il1r1 |
Information from provider
| Provider | Werner Muller |
| Provider affiliation | Faculty of Biology, Medicine and Health Science, University of Manchester |
| Genetic information | A targeting vector, encoding two loxP sites flanking exon 5 of the Il1r1 gene, was inserted. An FRT-flanked neomycin resistance (neo) cassette was placed downstream of the 3' loxP site. The gene targeting event was confirmed by PCR analysis. Flp-mediated recombination removed the FRT-flanked neo cassette. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6 males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased neutrophil cell number / MGI
- abnormal cell death / MGI
- increased body length / MGI
- increased body weight / MGI
- weight loss / MGI
- decreased anxiety-related response / MGI
- hypoactivity / MGI
- abnormal inflammatory response / MGI
- increased circulating insulin level / MGI
- no abnormal phenotype detected / MGI
- abnormal nervous system electrophysiology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased immunoglobulin level / MGI
- abnormal neutrophil physiology / MGI
- enhanced wound healing / MGI
- increased growth rate / MGI
- increased liver weight / MGI
- delayed tooth eruption / MGI
- increased susceptibility to age related obesity / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- increased susceptibility to induced arthritis / MGI
- impaired febrile response / MGI
- abnormal lean body mass / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased circulating insulin-like growth factor I level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to experimental autoimmune uveoretinitis / MGI
- abnormal vascular wound healing / MGI
- increased bone resorption / MGI
- decreased eosinophil cell number / MGI
- decreased T cell number / MGI
- sepsis / MGI
- decreased T cell proliferation / MGI
- osteomyelitis / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- abnormal food intake / MGI
- increased percent body fat/body weight / MGI
- decreased circulating creatinine level / MGI
- decreased blood urea nitrogen level / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- increased circulating leptin level / MGI
- increased body mass index / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased circulating interleukin-6 level / MGI
- increased circulating interleukin-18 level / MGI
- decreased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased interleukin-6 secretion / MGI
- impaired neutrophil chemotaxis / MGI
- decreased transforming growth factor level / MGI
- increased gonadal fat pad weight / MGI
- increased abdominal fat pad weight / MGI
- increased inguinal fat pad weight / MGI
- increased mesenteric fat pad weight / MGI
- increased retroperitoneal fat pad weight / MGI
- enhanced contextual conditioning behavior / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased total body fat amount / MGI
- abnormal circulating serum amyloid protein level / MGI
- increased respiratory quotient / MGI
- abnormal microglial cell activation / MGI
- integument phenotype / MGI
- dental pulp necrosis / MGI
Literature references
- Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.;Abdulaal Wesam H, Walker Catherine R, Costello Ryan, Redondo-Castro Elena, Mufazalov Ilgiz A, Papaemmanouil Athina, Rothwell Nancy J, Allan Stuart M, Waisman Ari, Pinteaux Emmanuel, Müller Werner, ;2016;European journal of immunology;46;912-8; 26692072