CBA;B6-Tg(CD2-TNF)7Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:11020 |
| Citation information | RRID:IMSR_EM:11020 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CBA;B6-Tg(CD2-TNF)7Gkl/Flmg |
| Alternative name | CBA.B6-Tg(CD2-TNF)7Gkl/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD2-TNF)7Gkl |
| Gene/Transgene symbol | Tg(CD2-TNF)7Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Fleming |
| Genetic information | The transgene comprises the T cell specific human CD2 gene locus control region (LCR) linked to part of the human lymphotoxin and the entire human TNF gene. Transgene transmission was determined by Southern hybridisation analysis, and revealed the presence of 50 transgene copies. |
| Phenotypic information | Homozygous:Phenotype exhibited is more severe; specific reproduction scheme suggested under breeding to keep mice in heterozygosity.Heterozygous:Mice develop normally but with lymphoid organ abnormalities. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous CBA x C57BL/6 males |
Literature references
- Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.;Probert L, Keffer J, Corbella P, Cazlaris H, Patsavoudi E, Stephens S, Kaslaris E, Kioussis D, Kollias G, ;1993;Journal of immunology (Baltimore, Md. : 1950);151;1894-906; 8345187