IMPC phenotypes (gene matching)
B6.Cg-Map3k7tm1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:11024 |
| Citation information | RRID:IMSR_EM:11024 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Map3k7tm1Gkl/Flmg |
| Alternative name | B6.Cg-Map3k7 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Map3k7tm1Gkl |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | B.S.R.C. |
| Genetic information | An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2, which encodes part of the kinase domain including the ATP binding pocket. An additional loxP site was inserted downstream of exon 2. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6 males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal vascular regression / MGI
- microcephaly / MGI
- short tail / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal blood vessel morphology / MGI
- decreased embryo size / MGI
- edema / MGI
- pericardial edema / MGI
- hemorrhage / MGI
- small heart / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal pharyngeal arch artery morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- thin myocardium compact layer / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal vascular smooth muscle morphology / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- absent fibroblast proliferation / MGI
- embryo tissue necrosis / MGI
Literature references
- Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.;Eftychi Christina, Karagianni Niki, Alexiou Maria, Apostolaki Maria, Kollias George, ;2012;PloS one;7;e31550; 22348103