- aspermia / IMPC
- enlarged lymph nodes / IMPC
- germ cell defect / IMPC
- small testis / IMPC
- decreased prepulse inhibition / IMPC
- developmental dysplasia / IMPC
- small kidney / IMPC
- small seminal vesicle / IMPC
- increased circulating sodium level / IMPC
- microphthalmia / IMPC
- male infertility / IMPC
- spermatogenesis defect / IMPC
- hypoplasia / IMPC
C57BL/6NTac-Wdr62tm2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:11074 |
| Citation information | RRID:IMSR_EM:11074 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Wdr62tm2Ics/Ics |
| Alternative name | C57BL6NTac-Wdr62 tm2Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Wdr62tm2Ics |
| Gene/Transgene symbol | Wdr62 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | Exons 4 to 7 have been flanked by loxP sites to allow conditional deletion of Wdr62 gene. |
| Phenotypic information | Homozygous:No phenotypeHeterozygous:No phenotype |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- microcephaly / MGI
- right pulmonary isomerism / MGI
- abnormal liver morphology / MGI
- dextrocardia / MGI
- mesocardia / MGI
- thymus hypoplasia / MGI
- reduced fertility / MGI
- loss of cortex neurons / MGI
- abnormal nervous system physiology / MGI
- abnormal mitosis / MGI
- heterotaxia / MGI
- right aortic arch / MGI
- fetal growth retardation / MGI
- decreased neuronal precursor cell number / MGI
- tricuspid valve atresia / MGI
- thin cerebral cortex / MGI
- proportional dwarf / MGI
- abnormal mitotic spindle morphology / MGI
- abnormal mitotic spindle assembly checkpoint / MGI
- atrioventricular septal defect / MGI
- muscular ventricular septal defect / MGI
- d-loop transposition of the great arteries / MGI
- double outlet right ventricle, Taussig bing type / MGI
- dual inferior vena cava / MGI
- increased cell death / MGI
Information on how we integrate external resources can be found here
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