STOCK Rr152tm9.1Cog/Orl
| Status | Available to order |
| EMMA ID | EM:11091 |
| Citation information | RRID:IMSR_EM:11091 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Rr152tm9.1Cog/Orl |
| Alternative name | IRIS mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rr152tm9.1Cog |
| Gene/Transgene symbol | Rr152 |
Information from provider
| Provider | Yves Denizot |
| Provider affiliation | Immunology, UMR CNRS 7276 - University of Limoges |
| Genetic information | The Igh 3’ cluster regulatory region 152 (Rr152 or 3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3’RR contains four enhancer elements with hs1,2 flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a and hs3b); hs4 lies downstream of the palindrome. To explore the role of the 3’RR palindromic architecture in the context of the endogenous locus, we analysed IRIS mice with a deconstructing palindrome by fully eliminating left-side IRIS while maintaining all four core enhancer elements. |
| Phenotypic information | Severe decrease of somatic hypermutation in VH gene. Partial decrease in class switch recombination and germline transcription. Number of B-cells not affected. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous 129S1/Sv-Oca2<+> Tyr<+> Kitl |
Literature references
- Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.;Saintamand Alexis, Vincent-Fabert Christelle, Garot Armand, Rouaud Pauline, Oruc Zeliha, Magnone Virginie, Cogné Michel, Denizot Yves, ;2016;Nature communications;7;10730; 26883548