STOCK Rr152tm10.1Cog/Orl
| Status | Available to order |
| EMMA ID | EM:11092 |
| Citation information | RRID:IMSR_EM:11092 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Rr152tm10.1Cog/Orl |
| Alternative name | Delta2-3'RR-deficient mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rr152tm10.1Cog |
| Gene/Transgene symbol | Rr152 |
Information from provider
| Provider | Yves Denizot |
| Provider affiliation | UMR CNRS 6101 |
| Genetic information | The Igh 3’ cluster regulatory region 152 (Rr152 or 3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3’RR contains four enhancer elements with hs1,2 flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a and hs3b); hs4 lies downstream of the palindrome. We generated and analysed mice without the left part of the 3'RR (hs3a-IRIS-hs1,2): Delta2-3'RR-deficient mice. |
| Phenotypic information | Homozygous:Decrease of somatic hypermutation rate in VH gene. Decrease of class switch recombination. Decrease in circulating Ig levels. Decrease of germinal transcription of IgH genes.Heterozygous:--- |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous 129 males |
Literature references
- Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.;Saintamand Alexis, Vincent-Fabert Christelle, Garot Armand, Rouaud Pauline, Oruc Zeliha, Magnone Virginie, Cogné Michel, Denizot Yves, ;2016;Nature communications;7;10730; 26883548