MGI phenotypes (allele matching)
B6.129P2-Ccr5tm1Blck/Biat
| Status | Available to order |
| EMMA ID | EM:11146 |
| Citation information | RRID:IMSR_EM:11146 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Ccr5tm1Blck/Biat |
| Alternative name | 5-B |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ccr5tm1Blck |
| Gene/Transgene symbol | Ccr5 |
Information from provider
| Provider | Bruno Luckow |
| Provider affiliation | Nephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV |
| Genetic information | The chemokine receptor Ccr5 has been inactivated by homologous recombination in ES cells. The mutant mice carry a lacZ reporter gene. They have been backcrossed to the C57BL/6NCrl genetic background. |
| Phenotypic information | Homozygous:Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Ccr5 plays specific roles in innate immunity and organ-specific leukocyte trafficking during host defense against Cryptococcus neoformans. Ccr5-deficient mice show a reduction of allograft rejection in heart and kidney transplantation experiments, diminished transplant arteriosclerosis and a shift towards M2 macrophage polarization.Heterozygous:unknown, but most likely wildtype phenotype |
| Breeding history | N16+F5 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous Other (please specify below) males |
Disease and phenotype information
MGI phenotypes (gene matching)
- altered response to myocardial infarction / MGI
- abnormal locomotor behavior / MGI
- abnormal spatial learning / MGI
- abnormal cardiovascular system physiology / MGI
- decreased inflammatory response / MGI
- decreased susceptibility to viral infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal leukocyte physiology / MGI
- abnormal conditioned taste aversion behavior / MGI
- abnormal cytokine secretion / MGI
- liver failure / MGI
- increased alcohol consumption / MGI
- abnormal leukocyte adhesion / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- abnormal glial cell physiology / MGI
- impaired macrophage chemotaxis / MGI
- increased length of allograft survival / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- decreased T cell proliferation / MGI
- decreased susceptibility to injury / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- reproductive system phenotype / MGI
- increased susceptibility to fungal infection / MGI
- abnormal heart size / MGI
- corneal vascularization / MGI
- increased susceptibility to type IV hypersensitivity reaction / MGI
- increased NK T cell number / MGI
- abnormal NK T cell physiology / MGI
- decreased NK cell number / MGI
- abnormal Kupffer cell morphology / MGI
- abnormal long term spatial reference memory / MGI
- increased IgG1 level / MGI
- decreased susceptibility to induced colitis / MGI
- increased interferon-gamma secretion / MGI
- decreased interleukin-1 beta secretion / MGI
- increased interleukin-4 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal astrocyte physiology / MGI
- abnormal Ito cell morphology / MGI
- abnormal cellular extravasation / MGI
- abnormal hepatocyte physiology / MGI
- decreased right ventricle systolic pressure / MGI
- mortality/aging / MGI
- increased fluid intake / MGI
- decreased microglial cell activation / MGI
Literature references
- Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice.;Luckow Bruno, Joergensen Joanne, Chilla Silvia, Li Jian-Ping, Henger Anna, Kiss Eva, Wieczorek Grazyna, Roth Lukas, Hartmann Nicole, Hoffmann Reinhard, Kretzler Matthias, Nelson Peter J, Pérez de Lema Guillermo, Maier Holger, Wurst Wolfgang, Balling Rudi, Pfeffer Klaus, Gröne Hermann-Josef, Schlöndorff Detlef, Zerwes Hans-Günter, ;2004;European journal of immunology;34;2568-78; 15307189