MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129X1-Esr1tm1Gust/Kctt
| Status | Available to order |
| EMMA ID | EM:11179 |
| Citation information | RRID:IMSR_EM:11179 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129X1-Esr1tm1Gust/Kctt |
| Alternative name | B6.129X1-Esr1tm1Gust |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Esr1tm1Gust |
| Gene/Transgene symbol | Esr1 |
Information from provider
| Provider | Per Antonson |
| Provider affiliation | Department of Biosciences and Nutrition, Karolinska Institutet |
| Genetic information | Floxed ERa mice. |
| Phenotypic information | Homozygous:Floxed mice, no phenotype without cre expression.Heterozygous:Floxed mice, no phenotype without cre expression. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Estrogen resistance syndrome / Orphanet_785
MGI phenotypes (gene matching)
- increased white adipose tissue amount / MGI
- increased bone mineral density / MGI
- decreased bone mineral density / MGI
- decreased compact bone thickness / MGI
- abnormal vertebrae morphology / MGI
- abnormal bone marrow cell number / MGI
- impaired fertilization / MGI
- cortical renal glomerulopathies / MGI
- abnormal mammary gland development / MGI
- abnormal branching of the mammary ductal tree / MGI
- decreased thymocyte number / MGI
- abnormal hypothalamus morphology / MGI
- abnormal uterus morphology / MGI
- uterus hypoplasia / MGI
- abnormal ovary morphology / MGI
- impaired ovarian folliculogenesis / MGI
- abnormal ovarian folliculogenesis / MGI
- abnormal ovarian follicle morphology / MGI
- absent mature ovarian follicles / MGI
- absent corpus luteum / MGI
- abnormal vagina morphology / MGI
- abnormal vagina epithelium morphology / MGI
- abnormal testis morphology / MGI
- seminiferous tubule degeneration / MGI
- abnormal spermatogenesis / MGI
- decreased body length / MGI
- increased body weight / MGI
- obese / MGI
- decreased body weight / MGI
- increased body size / MGI
- increased aggression towards mice / MGI
- increased aggression towards females / MGI
- abnormal social investigation / MGI
- abnormal mating receptivity / MGI
- reduced male mating frequency / MGI
- abnormal pup retrieval / MGI
- pup cannibalization / MGI
- abnormal maternal nurturing / MGI
- hyperactivity / MGI
- abnormal skeleton physiology / MGI
- abnormal osteoclast physiology / MGI
- increased circulating HDL cholesterol level / MGI
- abnormal vasodilation / MGI
- failure of embryo implantation / MGI
- increased circulating follicle stimulating hormone level / MGI
- increased circulating luteinizing hormone level / MGI
- thymus hypoplasia / MGI
- reduced male fertility / MGI
- infertility / MGI
- male infertility / MGI
- female infertility / MGI
- ovary cysts / MGI
- abnormal skeleton development / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal kidney physiology / MGI
- abnormal B cell differentiation / MGI
- abnormal reproductive system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal innervation / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal B cell number / MGI
- abnormal immunoglobulin level / MGI
- increased vertical activity / MGI
- abnormal epididymis morphology / MGI
- small uterus / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- abnormal nociception after inflammation / MGI
- glomerulonephritis / MGI
- decreased vertical activity / MGI
- short tibia / MGI
- decreased circulating testosterone level / MGI
- increased circulating testosterone level / MGI
- decreased heart weight / MGI
- increased growth rate / MGI
- albuminuria / MGI
- abnormal bone mineralization / MGI
- increased urine protein level / MGI
- no phenotypic analysis / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- abnormal cell migration / MGI
- short femur / MGI
- testicular atrophy / MGI
- decreased ovulation rate / MGI
- impaired granulosa cell differentiation / MGI
- abnormal uterus development / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal male reproductive system physiology / MGI
- abnormal female reproductive system physiology / MGI
- abnormal thymus physiology / MGI
- abnormal bone structure / MGI
- decreased aggression towards males / MGI
- decreased aggression towards mice / MGI
- impaired passive avoidance behavior / MGI
- abnormal vascular endothelial cell physiology / MGI
- decreased bone mass / MGI
- short ulna / MGI
- altered response of heart to induced stress / MGI
- decreased length of long bones / MGI
- decreased circulating insulin-like growth factor I level / MGI
- abnormal efferent ductules of testis morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- abnormal class switch recombination / MGI
- ovary hemorrhage / MGI
- abnormal testis weight / MGI
- decreased testis weight / MGI
- abnormal vascular wound healing / MGI
- decreased energy expenditure / MGI
- abnormal endometrium morphology / MGI
- decreased male germ cell number / MGI
- increased uterus weight / MGI
- decreased uterus weight / MGI
- enlarged uterus / MGI
- abnormal epididymis epithelium morphology / MGI
- decreased thymus weight / MGI
- increased osteoclast cell number / MGI
- decreased osteoblast cell number / MGI
- decreased bone strength / MGI
- decreased B cell number / MGI
- increased double-positive T cell number / MGI
- decreased circulating prolactin level / MGI
- increased luteinizing hormone level / MGI
- increased circulating cholesterol level / MGI
- decreased circulating estradiol level / MGI
- increased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- adipose tissue phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal circulating protein level / MGI
- hyporesponsive to tactile stimuli / MGI
- increased circulating glucose level / MGI
- teratozoospermia / MGI
- decreased lung weight / MGI
- abnormal pituitary gland physiology / MGI
- decreased aggression / MGI
- increased circulating leptin level / MGI
- decreased long bone epiphyseal plate size / MGI
- abnormal rete testis morphology / MGI
- dilated rete testis / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- decreased mature B cell number / MGI
- decreased immature B cell number / MGI
- decreased lactotroph cell number / MGI
- increased spleen germinal center number / MGI
- abnormal mesonephros morphology / MGI
- increased IgG3 level / MGI
- abnormal spleen physiology / MGI
- abnormal lymph node cell ratio / MGI
- anovulation / MGI
- abnormal physiological response to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- detached sperm flagellum / MGI
- vagina hypoplasia / MGI
- absent estrous cycle / MGI
- uterus cysts / MGI
- endometrium hyperplasia / MGI
- decreased endometrial gland number / MGI
- increased white fat cell size / MGI
- increased white fat cell number / MGI
- dilated efferent ductules of testis / MGI
- abnormal internal male genitalia morphology / MGI
- enlarged endometrial glands / MGI
- dilated seminiferous tubules / MGI
- abnormal bone marrow cell physiology / MGI
- increased gonadal fat pad weight / MGI
- increased epididymal fat pad weight / MGI
- increased inguinal fat pad weight / MGI
- increased mammary fat pad weight / MGI
- increased parametrial fat pad weight / MGI
- increased renal fat pad weight / MGI
- increased retroperitoneal fat pad weight / MGI
- abnormal secondary ovarian follicle morphology / MGI
- increased theca cell number / MGI
- ovarian follicular cyst / MGI
- abnormal superovulation / MGI
- abnormal uterus physiology / MGI
- decreased birth weight / MGI
- abnormal chondrocyte physiology / MGI
- spermatic granuloma / MGI
- failure of ejaculation / MGI
- increased total body fat amount / MGI
- decreased bone mineral content / MGI
- increased compact bone area / MGI
- decreased compact bone area / MGI
- decreased primordial ovarian follicle number / MGI
- renal glomerulus hypertrophy / MGI
- expanded mesangial matrix / MGI
- abnormal seminiferous tubule epithelium morphology / MGI
- abnormal cremaster muscle morphology / MGI
- abnormal volumetric bone mineral density / MGI
- increased volumetric bone mineral density / MGI
- decreased volumetric bone mineral density / MGI
- decreased areal bone mineral density / MGI
- decreased bone ossification / MGI
- decreased bone mineralization / MGI
- renal glomerular immunoglobulin deposits / MGI
Literature references
- Generation of ERα-floxed and knockout mice using the Cre/LoxP system.;Antonson P, Omoto Y, Humire P, Gustafsson J-Å, ;2012;Biochemical and biophysical research communications;424;710-6; 22800760
- Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.;Windahl Sara H, Börjesson Anna E, Farman Helen H, Engdahl Cecilia, Movérare-Skrtic Sofia, Sjögren Klara, Lagerquist Marie K, Kindblom Jenny M, Koskela Antti, Tuukkanen Juha, Divieti Pajevic Paola, Feng Jian Q, Dahlman-Wright Karin, Antonson Per, Gustafsson Jan-Åke, Ohlsson Claes, ;2013;Proceedings of the National Academy of Sciences of the United States of America;110;2294-9; 23345419
- Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action.;Matic Marko, Bryzgalova Galyna, Gao Hui, Antonson Per, Humire Patricia, Omoto Yoko, Portwood Neil, Pramfalk Camilla, Efendic Suad, Berggren Per-Olof, Gustafsson Jan-Åke, Dahlman-Wright Karin, ;2013;PloS one;8;e57458; 23451233
- aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.;Antonson Per, Matic Marko, Portwood Neil, Kuiper Raoul V, Bryzgalova Galyna, Gao Hui, Windahl Sara H, Humire Patricia, Ohlsson Claes, Berggren Per-Olof, Gustafsson Jan-Åke, Dahlman-Wright Karin, ;2014;PloS one;9;e85581; 24416430
- Identification of proteins highly expressed in uterine fluid from mice with hydrometra.;Antonson Per, Nalvarte Ivan, Varshney Mukesh, Xu Li, Windahl Sara H, Humire Patricia, Ohlsson Claes, Gustafsson Jan-Åke, Dahlman-Wright Karin, ;2015;Biochemical and biophysical research communications;466;650-5; 26393907
- Estrogen Receptor-α Knockout Mice.;Antonson Per, Humire Patricia, Gustafsson Jan-Åke, ;2016;Methods in molecular biology (Clifton, N.J.);1366;425-430; 26585154