B6.129S6-Car6tm1Pwp/Oulu

Status

Available to order

EMMA IDEM:11181
Citation informationRRID:IMSR_EM:11181 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameB6.129S6-Car6tm1Pwp/Oulu
Alternative nameCarbonic anhydrase 6; targeted mutation 1, Pei-wen Pan
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCar6tm1Pwp
Gene/Transgene symbolCar6

Information from provider

ProviderSeppo Parkkila
Provider affiliationMedicine and Life Sciences, Tampere University
Genetic informationExons 3 and 4 of the Car6 gene were replaced with a neo cassette.
Phenotypic informationHomozygous:
Car6 (-/-) mice are viable and fertile and have a normal life span. Histological analyses indicated a greater number of lymphoid follicles in the small intestinal Peyer's patches.

Heterozygous:
like wild-type
References
  • Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice.;Pan Pei-wen, Käyrä Katri, Leinonen Jukka, Nissinen Marja, Parkkila Seppo, Rajaniemi Hannu, ;2011;Transgenic research;20;675-98; 20835760
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland
Animals used for archivingheterozygous C57BL/6JOlaHsd males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal lymph node morphology / IMPC
  • enlarged thymus / IMPC
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • decreased lung elastance / IMPC
  • small testis / IMPC
  • abnormal tooth color / IMPC
  • abnormal testis morphology / IMPC
  • decreased NK cell number / IMPC
  • increased eosinophil cell number / IMPC
  • enlarged lymph nodes / IMPC
  • abnormal thymus morphology / IMPC
MGI phenotypes (allele matching)
  • abnormal Peyer's patch follicle morphology / MGI
  • digestive/alimentary phenotype / MGI
MGI phenotypes (gene matching)
  • abnormal Peyer's patch follicle morphology / MGI
  • digestive/alimentary phenotype / MGI

Literature references

  • Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice.;Pan Pei-wen, Käyrä Katri, Leinonen Jukka, Nissinen Marja, Parkkila Seppo, Rajaniemi Hannu, ;2011;Transgenic research;20;675-98; 20835760

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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