129(Cg)-Synb^tm1.2Ics/Orl

Status	Available to order
EMMA ID	EM:11298
Citation information	RRID:IMSR_EM:11298 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	129(Cg)-Synb^tm1.2Ics/Orl
Alternative name	129/sv Syncytin-B KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Synb^tm1.2Ics
Gene/Transgene symbol	Synb

Information from provider

Provider	Thierry Heidmann
Provider affiliation	Insitut Gustave Roussy, UMR9196 CNRS
Genetic information	Mice containing an excised copy of the syncytin-B open reading frame.
Phenotypic information	Homozygous: Homozygous null embryos display an impaired placentation, with late onset growth retardation and reduced neonate numbers. Heterozygous: no alteration
Breeding history	The original founder (B6.129/Sv) was backcrossed 10 times to 129/Sv. Then, four homozygous mutant siblings, obtained from two couples, were bred and the mutant strain was subsequently maintained in a homozygous state for more than 7 generations.
References	A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.;Dupressoir Anne, Vernochet Cécile, Harper Francis, Guégan Justine, Dessen Philippe, Pierron Gérard, Heidmann Thierry, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;E1164-73; 22032925 Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.;Redelsperger François, Raddi Najat, Bacquin Agathe, Vernochet Cécile, Mariot Virginie, Gache Vincent, Blanchard-Gutton Nicolas, Charrin Stéphanie, Tiret Laurent, Dumonceaux Julie, Dupressoir Anne, Heidmann Thierry, ;2016;PLoS genetics;12;e1006289; 27589388 Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.;Coudert Amélie E, Redelsperger François, Chabbi-Achengli Yasmine, Vernochet Cécile, Marty Caroline, Decrouy Xavier, Heidmann Thierry, de Vernejoul Marie-Christine, Dupressoir Anne, ;2019;Bone reports;11;100214; 31360740
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous 129 males

Disease and phenotype information

MGI phenotypes (allele matching)

decreased body weight / MGI
abnormal placenta labyrinth morphology / MGI
postnatal growth retardation / MGI
fetal growth retardation / MGI
abnormal placental labyrinth vasculature morphology / MGI
decreased fetal weight / MGI
preweaning lethality, incomplete penetrance / MGI
abnormal syncytiotrophoblast morphology / MGI

MGI phenotypes (gene matching)

decreased body weight / MGI
abnormal placenta labyrinth morphology / MGI
postnatal growth retardation / MGI
no phenotypic analysis / MGI
fetal growth retardation / MGI
abnormal placental labyrinth vasculature morphology / MGI
decreased fetal weight / MGI
preweaning lethality, incomplete penetrance / MGI
abnormal syncytiotrophoblast morphology / MGI

Literature references

A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.;Dupressoir Anne, Vernochet Cécile, Harper Francis, Guégan Justine, Dessen Philippe, Pierron Gérard, Heidmann Thierry, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;E1164-73; 22032925
Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.;Redelsperger François, Raddi Najat, Bacquin Agathe, Vernochet Cécile, Mariot Virginie, Gache Vincent, Blanchard-Gutton Nicolas, Charrin Stéphanie, Tiret Laurent, Dumonceaux Julie, Dupressoir Anne, Heidmann Thierry, ;2016;PLoS genetics;12;e1006289; 27589388
Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.;Coudert Amélie E, Redelsperger François, Chabbi-Achengli Yasmine, Vernochet Cécile, Marty Caroline, Decrouy Xavier, Heidmann Thierry, de Vernejoul Marie-Christine, Dupressoir Anne, ;2019;Bone reports;11;100214; 31360740

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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129(Cg)-Synbtm1.2Ics/Orl