MGI phenotypes (gene matching)
BKa.Cg-Thy1a Tg(TcraH-Y,TcrbH-Y)71Vbo/VboOrl
| Status | Available to order |
| EMMA ID | EM:00113 |
| Citation information | RRID:IMSR_EM:00113 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | BKa.Cg-Thy1a Tg(TcraH-Y,TcrbH-Y)71Vbo/VboOrl |
| Alternative name | HY1.1 (Tcr-ab) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TcraH-Y,TcrbH-Y)71Vbo, Thy1a |
| Gene/Transgene symbol | Tg(TcraH-Y,TcrbH-Y)71Vbo, Thy1 |
Information from provider
| Provider | H Von Boehmer |
| Provider affiliation | c/o CDTA-Orleans |
| Phenotypic information | The transgenic mice express T-cell receptor alpha and beta specific for the male (H-Y) antigen, in the context of class I H-2Db MHC antigens (C57BL/Ka-Thy1.1 background). Tolerance in T-cell receptor transgenic mice involves deletion of transgene-expressing cells, including non-mature CD4+ CD8+ thymocytes. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Literature references
- Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.;Kisielow P, Blüthmann H, Staerz U D, Steinmetz M, von Boehmer H, ;1988;Nature;333;742-6; 3260350
- T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous alpha- and beta-genes.;Blüthmann H, Kisielow P, Uematsu Y, Malissen M, Krimpenfort P, Berns A, von Boehmer H, Steinmetz M, ;1988;Nature;334;156-9; 3260351
- N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.;Zhou Raymond W, Mkhikian Haik, Grigorian Ani, Hong Amanda, Chen David, Arakelyan Araz, Demetriou Michael, ;2014;Nature immunology;15;1038-45; 25263124
- ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.;Nakahama Taisuke, Kato Yuki, Kim Jung In, Vongpipatana Tuangtong, Suzuki Yutaka, Walkley Carl R, Kawahara Yukio, ;2018;EMBO reports;19;2156-2168; 30361393
- ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways.;Vongpipatana Tuangtong, Nakahama Taisuke, Shibuya Toshiharu, Kato Yuki, Kawahara Yukio, ;2020;Journal of immunology (Baltimore, Md. : 1950);204;; 32169840