C57BL/6-Egr2tm1Pwg/H

Status

Available to order

EMMA IDEM:11391
Citation informationRRID:IMSR_EM:11391 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6-Egr2tm1Pwg/H
Alternative nameEgr2-GFP knock-in mouse
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolEgr2tm1Pwg
Gene/Transgene symbolEgr2

Information from provider

ProviderSuling Li
Provider affiliationLife Science, Brunel University
Genetic informationGFP expression under the Egr2 promoter; mutant mice were generated on the C57BL/6 background (reference: Miao T et al., JEM, 2017).
Phenotypic informationHomozygous:
Egr2-GFP knock-in mice, with GFP expressed under the Egr2 promoter. All cells which express Egr2 gene also express the GFP gene, showing green florescence (ref: Miao T et al., JEM, 2017).

Heterozygous:
The mice show healthy breeding in general.
References
  • Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.;Miao Tizong, Symonds Alistair L J, Singh Randeep, Symonds Janine D, Ogbe Ane, Omodho Becky, Zhu Bo, Li Suling, Wang Ping, ;2017;The Journal of experimental medicine;214;1787-1808; 28487311
  • Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.;Symonds Alistair L J, Miao Tizong, Busharat Zabreen, Li Suling, Wang Ping, ;2023;Cancer immunology, immunotherapy : CII;72;1139-1151; 36342511
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal mandible morphology / MGI
  • tremors / MGI
  • weakness / MGI
  • paralysis / MGI
  • hindlimb paralysis / MGI
  • abnormal myelination / MGI
  • abnormal rhombomere morphology / MGI
  • abnormal motor neuron morphology / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal abducens nerve morphology / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • abnormal vagus nerve morphology / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal geniculate ganglion morphology / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • abnormal glossopharyngeal ganglion morphology / MGI
  • abnormal vagus ganglion morphology / MGI
  • abnormal Schwann cell morphology / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • delayed eyelid opening / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • impaired limb coordination / MGI
  • postnatal growth retardation / MGI
  • respiratory distress / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal skeleton development / MGI
  • abnormal neural tube morphology / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal somatic nervous system morphology / MGI
  • short tibia / MGI
  • abnormal cochlear ganglion morphology / MGI
  • abnormal bone mineralization / MGI
  • no phenotypic analysis / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • short femur / MGI
  • decreased width of hypertrophic chondrocyte zone / MGI
  • abnormal long bone morphology / MGI
  • abnormal bone structure / MGI
  • short radius / MGI
  • fusion of glossopharyngeal and vagus nerve / MGI
  • decreased length of long bones / MGI
  • increased pulmonary respiratory rate / MGI
  • abnormal neuronal migration / MGI
  • abnormal hindbrain development / MGI
  • decreased diameter of long bones / MGI
  • decreased diameter of femur / MGI
  • decreased diameter of radius / MGI
  • decreased diameter of tibia / MGI
  • decreased nerve conduction velocity / MGI
  • enlarged aortic valve / MGI
  • thick aortic valve cusps / MGI
  • thick pulmonary valve cusps / MGI
  • integument phenotype / MGI
  • lethality at weaning, complete penetrance / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • increased Schwann cell proliferation / MGI
  • decreased rhombomere 3 size / MGI
  • absent rhombomere 3 / MGI
  • decreased rhombomere 5 size / MGI
  • absent rhombomere 5 / MGI
  • decreased rhombomere 6 size / MGI

Literature references

  • Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.;Miao Tizong, Symonds Alistair L J, Singh Randeep, Symonds Janine D, Ogbe Ane, Omodho Becky, Zhu Bo, Li Suling, Wang Ping, ;2017;The Journal of experimental medicine;214;1787-1808; 28487311
  • Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.;Symonds Alistair L J, Miao Tizong, Busharat Zabreen, Li Suling, Wang Ping, ;2023;Cancer immunology, immunotherapy : CII;72;1139-1151; 36342511

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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