129-Prnptm2.1Jcmn/H

Status

Available to order

EMMA IDEM:11449
Citation informationRRID:IMSR_EM:11449 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain name129-Prnptm2.1Jcmn/H
Alternative nameHuV
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolPrnptm2.1Jcmn
Gene/Transgene symbolPrnp

Information from provider

ProviderJean Manson
Provider affiliationThe Roslin Institute
Genetic informationPrion protein amino acids 40-254 encoded by the ORF have been changed from mouse to human. These mice express PRNP valine at codon 129.
Phenotypic informationMice express PRNP valine at codon 129. Mice develop and live normally with no overt phenotype
References
  • Predicting susceptibility and incubation time of human-to-human transmission of vCJD.;Bishop M T, Hart P, Aitchison L, Baybutt H N, Plinston C, Thomson V, Tuzi N L, Head M W, Ironside J W, Will R G, Manson J C, ;2006;The Lancet. Neurology;5;393-8; 16632309
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • impaired fertilization / MGI
  • abnormal spleen morphology / MGI
  • tremors / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • abnormal thalamus morphology / MGI
  • abnormal cerebellum morphology / MGI
  • Purkinje cell degeneration / MGI
  • decreased Purkinje cell number / MGI
  • abnormal cerebellar molecular layer / MGI
  • thin cerebellar molecular layer / MGI
  • abnormal retina morphology / MGI
  • ataxia / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • reduced long term potentiation / MGI
  • abnormal sleep pattern / MGI
  • abnormal body temperature homeostasis / MGI
  • male infertility / MGI
  • premature death / MGI
  • abnormal muscle physiology / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • gliosis / MGI
  • abnormal CNS synaptic transmission / MGI
  • neurodegeneration / MGI
  • spongiform encephalopathy / MGI
  • decreased vertical activity / MGI
  • abnormal inhibitory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • no phenotypic analysis / MGI
  • increased neuron apoptosis / MGI
  • neuron degeneration / MGI
  • astrocytosis / MGI
  • abnormal voluntary movement / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • impaired acrosome reaction / MGI
  • abnormal behavior / MGI
  • abnormal neuronal precursor proliferation / MGI
  • decreased susceptibility to prion infection / MGI
  • increased susceptibility to prion infection / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • teratozoospermia / MGI
  • brain vacuoles / MGI
  • abnormal brain white matter morphology / MGI
  • abnormal hippocampus CA1 region morphology / MGI
  • decreased neuron number / MGI
  • abnormal neuron differentiation / MGI
  • abnormal neuron proliferation / MGI
  • decreased brain copper level / MGI
  • enlarged brain ventricles / MGI
  • cerebellum atrophy / MGI
  • altered susceptibility to prion infection / MGI

Literature references

  • Predicting susceptibility and incubation time of human-to-human transmission of vCJD.;Bishop M T, Hart P, Aitchison L, Baybutt H N, Plinston C, Thomson V, Tuzi N L, Head M W, Ironside J W, Will R G, Manson J C, ;2006;The Lancet. Neurology;5;393-8; 16632309

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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