MGI phenotypes (allele matching)
B6.129(FVB)-Igf1rtm1.2Mhz/Orl
| Status | Available to order |
| EMMA ID | EM:00115 |
| Citation information | RRID:IMSR_EM:00115 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129(FVB)-Igf1rtm1.2Mhz/Orl |
| Alternative name | IGF-1R+/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Igf1rtm1.2Mhz |
| Gene/Transgene symbol | Igf1r |
Information from provider
| Provider | Martin HOLZENBERGER |
| Provider affiliation | Université Pierre et Marie Curie, INSERM, U938, Hôpital Saint Antoine |
| Phenotypic information | Homozygous:The mutant mice are generated by targeting the endogenous gene with a replacement construct to flox the essential exon 3 and subsequently eliminate exon 3 using an EIIa-cre recombinase deleter transgenic line (MGI:2137691). Absence of exon 3 from the Igf1r endogenous locus results in a non-functional receptor protein that is truncated at lysine 183. The mutant mice are lacking exon 3 of the Igf1r (IGF-I) receptor gene and do not express functional IGF-I receptor. Homozygous null mutants (Igf1r-/-) are not viable, so heterozygous knock-out mice (Igf1r+/-) are used for breeding. Heterozygous:Igf1r+/- mice live on average 26% longer than their wild-type littermates and display enhanced resistance to oxidative stress. |
| Breeding history | Backcrossed to C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Growth delay due to insulin-like growth factor I resistance / Orphanet_73273
MGI phenotypes (gene matching)
- abnormal cochlea morphology / MGI
- abnormal lateral semicircular canal morphology / MGI
- delayed bone ossification / MGI
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- small hair follicles / MGI
- abnormal liver morphology / MGI
- muscle hypoplasia / MGI
- decreased oligodendrocyte progenitor number / MGI
- abnormal spinal cord morphology / MGI
- atelectasis / MGI
- translucent skin / MGI
- thin epidermis / MGI
- thin epidermis stratum spinosum / MGI
- decreased body weight / MGI
- cyanosis / MGI
- postnatal growth retardation / MGI
- respiratory failure / MGI
- abnormal postnatal growth/weight/body size / MGI
- abnormal muscle morphology / MGI
- hydrops fetalis / MGI
- abnormal semicircular canal morphology / MGI
- abnormal posterior semicircular canal morphology / MGI
- abnormal cochlear sensory epithelium morphology / MGI
- abnormal bony labyrinth / MGI
- abnormal cochlear inner hair cell morphology / MGI
- decreased cochlear inner hair cell number / MGI
- abnormal cochlear outer hair cell morphology / MGI
- decreased cochlear outer hair cell number / MGI
- decreased cochlear hair cell number / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal cochlear hair cell development / MGI
- abnormal brainstem morphology / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- decreased birth weight / MGI
- prenatal growth retardation / MGI
- abnormal inner hair cell kinocilium morphology / MGI
- neonatal lethality, complete penetrance / MGI
Literature references
- A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit.;Holzenberger M, Leneuve P, Hamard G, Ducos B, Perin L, Binoux M, Le Bouc Y, ;2000;Endocrinology;141;2557-66; 10875258
- IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.;Holzenberger Martin, Dupont Joëlle, Ducos Bertrand, Leneuve Patricia, Géloën Alain, Even Patrick C, Cervera Pascale, Le Bouc Yves, ;2003;Nature;421;182-7; 12483226
- The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.;Abbas Afroze, Imrie Helen, Viswambharan Hema, Sukumar Piruthivi, Rajwani Adil, Cubbon Richard M, Gage Matthew, Smith Jessica, Galloway Stacey, Yuldeshava Nadira, Kahn Matthew, Xuan Shouhong, Grant Peter J, Channon Keith M, Beech David J, Wheatcroft Stephen B, Kearney Mark T, ;2011;Diabetes;60;2169-78; 21677284
- IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells.;Huynh Hoangdinh, Zheng Junke, Umikawa Masato, Zhang Chaozheng, Silvany Robert, Iizuka Satoru, Holzenberger Martin, Zhang Wei, Zhang Cheng Cheng, ;2011;Blood;118;3236-43; 21821709
- Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.;Imrie Helen, Viswambharan Hema, Sukumar Piruthivi, Abbas Afroze, Cubbon Richard M, Yuldasheva Nadira, Gage Matthew, Smith Jessica, Galloway Stacey, Skromna Anna, Rashid Sheik Taqweer, Futers T Simon, Xuan Shouhong, Gatenby V Kate, Grant Peter J, Channon Keith M, Beech David J, Wheatcroft Stephen B, Kearney Mark T, ;2012;Diabetes;61;2359-68; 22733797
- Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord.;Hwang Dong Hoon, Park Hee Hwan, Shin Hae Young, Cui Yuexian, Kim Byung Gon, ;2018;Experimental neurobiology;27;489-507; 30636901