B6.Cg-Tg(Camk2a-Ppp3ca*)CN98Kndl/Orl

Status	Available to order
EMMA ID	EM:01152
Citation information	RRID:IMSR_EM:01152 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(Camk2a-Ppp3ca*)CN98Kndl/Orl
Alternative name	CN98
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Camk2a-Ppp3ca*)CN98Kndl
Gene/Transgene symbol	Tg(Camk2a-Ppp3ca*)CN98Kndl

Information from provider

Provider	Isabelle Mansuy
Provider affiliation	Institute of Cell, Swiss Federal Institute of technologies
Genetic information	Transgenic mice that overexpress a truncated form of calcineurin (Ppp3ca) under the control of the CaMKII-alpha promoter.
Phenotypic information	Mice expressing this transgene show increased calcium-dependent phosphatase activity in the hippocampus. These mice have normal short-term memory but defective long-term memory on both a spatial task and on a visual recognition task.
Breeding history	N=10
References	Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.;Winder D G, Mansuy I M, Osman M, Moallem T M, Kandel E R, ;1998;Cell;92;25-37; 9489697 Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.;Mansuy I M, Mayford M, Jacob B, Kandel E R, Bach M E, ;1998;Cell;92;39-49; 9489698

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Literature references

Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.;Winder D G, Mansuy I M, Osman M, Moallem T M, Kandel E R, ;1998;Cell;92;25-37; 9489697
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.;Mansuy I M, Mayford M, Jacob B, Kandel E R, Bach M E, ;1998;Cell;92;39-49; 9489698

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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Legally binding conditions for the transfer

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