B6;129S2-Dclre1ctm2.1Jpdv/Orl

Status

Available to order

EMMA IDEM:01156
Citation informationRRID:IMSR_EM:01156 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6;129S2-Dclre1ctm2.1Jpdv/Orl
Alternative nameArt F1
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolDclre1ctm2.1Jpdv
Gene/Transgene symbolDclre1c

Information from provider

ProviderJean-Pierre De Villartay
Provider affiliationCRBS (Centre de Recherche en Biomédecine), Inserm UMR 1109 (Immuno-Rhumatologie Moléculaire, IRM)
Genetic informationFloxed allele of the DNA cross-link repair 1C (Dclre1c or Artemis) gene. A loxP site was inserted upstream of exon 12 and a floxed neo cassette was inserted downstream of exon 12 (Exon11/loxP/Exon12/loxP/Exon13; 5'-ATAACTTCGTATAGCATACATTATACGAAGTTAT-3').
Phenotypic informationNone.
References
  • Reduced immunoglobulin class switch recombination in the absence of Artemis.;Rivera-Munoz Paola, Soulas-Sprauel Pauline, Le Guyader Gwenaël, Abramowski Vincent, Bruneau Sylvia, Fischer Alain, Pâques Frédéric, de Villartay Jean-Pierre, ;2009;Blood;114;3601-9; 19692705

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • decreased thymocyte number / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • arrested T cell differentiation / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • abnormal B cell differentiation / MGI
  • small lymph nodes / MGI
  • abnormal lymph node morphology / MGI
  • abnormal leukocyte physiology / MGI
  • absent CD4-positive, alpha beta T cells / MGI
  • induced chromosome breakage / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • decreased thymus weight / MGI
  • decreased B-1 B cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • abnormal cell physiology / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • decreased NK T cell number / MGI
  • increased NK cell number / MGI
  • absent T cells / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • increased pro-B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent immature B cells / MGI
  • abnormal mononuclear cell morphology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal T cell receptor beta chain V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • chromosomal instability / MGI
  • decreased splenocyte number / MGI
  • decreased DN1 thymic pro-T cell number / MGI
  • decreased DN4 thymocyte number / MGI
  • absent thymus cortex / MGI
  • increased central memory CD4-positive, alpha-beta T cell number / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased central memory CD8 positive, alpha-beta T cell number / MGI
  • increased effector memory CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI
  • decreased response to antigen / MGI
  • impaired humoral immune response / MGI

Literature references

  • Reduced immunoglobulin class switch recombination in the absence of Artemis.;Rivera-Munoz Paola, Soulas-Sprauel Pauline, Le Guyader Gwenaël, Abramowski Vincent, Bruneau Sylvia, Fischer Alain, Pâques Frédéric, de Villartay Jean-Pierre, ;2009;Blood;114;3601-9; 19692705

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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