IMPC phenotypes (gene matching)
- decreased circulating serum albumin level / IMPC
B6N.129S5(B6J)-Galr2Gt(OST105469)Lex/Biat
| Status | Available to order |
| EMMA ID | EM:11615 |
| Citation information | RRID:IMSR_EM:11615 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129S5(B6J)-Galr2Gt(OST105469)Lex/Biat |
| Alternative name | B6N-Galr2 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Galr2Gt(OST105469)Lex |
| Gene/Transgene symbol | Galr2 |
Information from provider
| Provider | Barbara Kofler |
| Provider affiliation | Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University |
| Genetic information | Mice deficient for the GAL2-R gene were generated and licensed from Lexicon Genetics. The 5.17-kb gene-trap vector VICTR48 (viral construct for trapping) was inserted within the single intron of the murine Galr2 gene in a 129/SvEvBrd embryonic stem (ES) cell line clone (Zambrowicz et al. 2003). This Omnibank clone (OST105469; http://www.lexicon-genetics.com/discovery/omnibank.html) was used to obtain germ-line transmission of the disrupted Galr2 allele. The mouse line was first backcrossed onto the C57BL/6J background for at least 10 generations (Einstein et al., 2013) and then onto the C57BL/6N background for 4 generations (C57BL/6N genetic background was analyzed by Charles River). The mouse line is maintained on this background. |
| Phenotypic information | Homozygous:No phenotypes detected; described phenotypes of founder line: http://www.informatics.jax.org/allele/allgenoviews/MGI:3530476Heterozygous:No phenotypes detected. |
| Breeding history | The original mouse line (C57BL/6J x 129/SvEvBrd background) was backcrossed onto the C57BL/6J background for at least 10 generations (Einstein et al., 2013) and then backcrossed onto the C57BL/6N background for 4 generations. The mouse line is kept on this background. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous Other (please specify below) males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal L5 dorsal root ganglion morphology / MGI
- increased thermal nociceptive threshold / MGI
- decreased vertical activity / MGI
- abnormal excitatory postsynaptic potential / MGI
- increased T cell number / MGI
- decreased B cell number / MGI
- behavior/neurological phenotype / MGI
- impaired conditioned place preference behavior / MGI