B6;129P2-Rhd^tm1Goo/Orl

Status	Available to order
EMMA ID	EM:11706
Citation information	RRID:IMSR_EM:11706 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129P2-Rhd^tm1Goo/Orl
Alternative name	GOO1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Rhd^tm1Goo
Gene/Transgene symbol	Rhd

Information from provider

Provider	Dominique GOOSSENS
Provider affiliation	UMR_S1134-Inserm - Dept de recherches biologiques sur le globule rouge, Institut National de la Transfusion Sanguine-Inserm
Genetic information	Rhd (erythroid membrane protein) gene knock-out.
Phenotypic information	Homozygous: No clinical or cellular abnormalities, complete loss of erythrocyte membrane expression of Rhd, and of Icam4 (with consequent decreased adhesion to endothelial cell line) Heterozygous: Normal
Breeding history	129P2/OlaHsd x C57BL/6 background.
References	Generation and characterisation of Rhd and Rhag null mice.;Goossens Dominique, Trinh-Trang-Tan Marie-Marcelle, Debbia Martine, Ripoche Pierre, Vilela-Lamego Camilo, Louache Fawzia, Vainchenker William, Colin Yves, Cartron Jean-Pierre, ;2010;British journal of haematology;148;161-72; 19807729 Generation of mice with inactivated Rh or Rhag genes.;Goossens D, Bony V, Gane P, Colin Y, Cartron J-P, ;2006;Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine;13;164-6; 16581281
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous 129P2/OlaHsd x C57BL/6 males, wild-type C57BL/6 females
Stage of embryos	2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Rh deficiency syndrome / Orphanet_71275

IMPC phenotypes (gene matching)

increased exploration in new environment / IMPC
decreased mean corpuscular hemoglobin / IMPC
decreased hemoglobin content / IMPC
decreased mean corpuscular hemoglobin concentration / IMPC
decreased mean corpuscular volume / IMPC
decreased circulating cholesterol level / IMPC
abnormal skin condition / IMPC
decreased circulating free fatty acids level / IMPC
decreased circulating alkaline phosphatase level / IMPC
decreased circulating HDL cholesterol level / IMPC

MGI phenotypes (gene matching)

decreased mean corpuscular volume / MGI
decreased hemoglobin content / MGI
abnormal erythrocyte physiology / MGI
decreased mean corpuscular hemoglobin concentration / MGI
increased circulating iron level / MGI

Literature references

Generation and characterisation of Rhd and Rhag null mice.;Goossens Dominique, Trinh-Trang-Tan Marie-Marcelle, Debbia Martine, Ripoche Pierre, Vilela-Lamego Camilo, Louache Fawzia, Vainchenker William, Colin Yves, Cartron Jean-Pierre, ;2010;British journal of haematology;148;161-72; 19807729
Generation of mice with inactivated Rh or Rhag genes.;Goossens D, Bony V, Gane P, Colin Y, Cartron J-P, ;2006;Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine;13;164-6; 16581281

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6;129P2-Rhdtm1Goo/Orl