MGI phenotypes (allele matching)
B6.129-Rps19tm1Dahl/Kctt
| Status | Available to order |
| EMMA ID | EM:01172 |
| Citation information | RRID:IMSR_EM:01172 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Rps19tm1Dahl/Kctt |
| Alternative name | B6.129-Rps19tmUU |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rps19tm1Dahl |
| Gene/Transgene symbol | Rps19 |
Information from provider
| Provider | Niklas Dahl |
| Provider affiliation | Genetics and Pathology |
| Genetic information | The 5´UTR and the coding exons 1 to 4 (of a total of five) are deleted by targeted homologous recombination. Gene sequence is replaced by a neomycin resistance gene driven by a thymidine kinase promoter. |
| Phenotypic information | Homozygosity for the Rps19 disruption results in early embryonic lethality prior to implantation. Mice heterozygous for the disruption are viable, reproduce and exhibit no abnormalities in major organs, including the hematopoietic system. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Blackfan-Diamond anemia / Orphanet_124
Literature references
- Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.;Matsson Hans, Davey Edward J, Draptchinskaia Natalia, Hamaguchi Isao, Ooka Andreas, Levéen Per, Forsberg Erik, Karlsson Stefan, Dahl Niklas, ;2004;Molecular and cellular biology;24;4032-7; 15082795