| Status | Available to order |
| EMMA ID | EM:11736 |
| Citation information | RRID:IMSR_EM:11736 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C;129P2-Pi4k2aGt(AK0094)Wtsi/H |
| Alternative name | Pi4k2aGt(AK0094)Wtsi Balb/c |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Pi4k2aGt(AK0094)Wtsi |
| Gene/Transgene symbol | Pi4k2a |
| Provider | Paul Simons |
| Provider affiliation | Centre for Amyloidosis and Acute Phase Proteins, , UCL |
| Genetic information | Gene trap (functional null) of Pi4k2a. |
| Phenotypic information | Homozygous:Age-related neurodegeneration: progressive degeneration of ascending and descending tracts in the spinal cord, and death of cerebellar Purkinje cells. Peripheral nerves are normal. Young adults appear normal; tremor, hindlimb clasping and spastic gait appear on ageing (onset 4-12 months). Perturbed packing of von Willebrand factor in Weibel-Palade bodies of endothelial cells.Heterozygous:Heterozygotes appear normal. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
