C57BL/6N-Tg(Vav1-BCL2L1)670Biat/Biat

Status	Available to order
EMMA ID	EM:11778
Citation information	RRID:IMSR_EM:11778 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Tg(Vav1-BCL2L1)670Biat/Biat
Alternative name	C57BL/6N-Tg(Vav-BCLX)670Biat, or Vav-BCLX
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Vav1-BCL2L1)670Biat
Gene/Transgene symbol	Tg(Vav1-BCL2L1)670Biat

Information from provider

Provider	Andreas Villunger
Provider affiliation	Division of Developmental Immunology, Medical University Innsbruck
Genetic information	Random transgene insertion of human FLAG-BCLX cDNA into C57BL/6N oocytes; Vav-BCLX TG mice were generated by pronuclear injection of the VavP vectors [Ogilvy 1999 see reference below] encoding human FLAG-BCLX (BCL2L1) cDNA into C57BL/6N oocytes. The founder lines were designated as C57BL/6N-Tg(Vav-BCLX)670, 671, 672Biat, or Vav-BCLX TG line A, B, C. Only C57BL/6N-Tg(Vav-BCLX)670Biat (Vav-BCLX TG line A) is submitted. REFERENCE: Ogilvy, S., Metcalf, D., Gibson, L., Bath, M. L., Harris, A. W. & Adams, J. M. (1999) Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment, Blood. 94, 1855-1863.
Phenotypic information	Homozygous: NA Heterozygous: Cell death resistance of leukocytes
References	Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.;Tuzlak Selma, Haschka Manuel D, Mokina Anna-Maria, Rülicke Thomas, Cory Suzanne, Labi Verena, Villunger Andreas, ;2018;The FEBS journal;285;1403-1418; 29498802
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6N males

Literature references

Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.;Tuzlak Selma, Haschka Manuel D, Mokina Anna-Maria, Rülicke Thomas, Cory Suzanne, Labi Verena, Villunger Andreas, ;2018;The FEBS journal;285;1403-1418; 29498802

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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