B6;129-Egr1tm1Pch/Orl

Status

Available to order

EMMA IDEM:11826
Citation informationRRID:IMSR_EM:11826 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6;129-Egr1tm1Pch/Orl
Alternative nameKrox24 lacZ
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolEgr1tm1Pch
Gene/Transgene symbolEgr1

Information from provider

ProviderCarole Desmarquet-Trin-Dinh
Provider affiliationEquipe Developpement du Systeme Nerveux IBENS, INSERM U 1024, CNRS UMR 8197, Ecole Normale Superieure
Genetic informationInsertion of lacZ gene in Krox24/Egr1 locus.
Phenotypic informationHomozygous:
Infertile (hormonal problems).

Heterozygous:
Nothing to report.
References
  • The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.;Lemaire P, Vesque C, Schmitt J, Stunnenberg H, Frank R, Charnay P, ;1990;Molecular and cellular biology;10;3456-67; 2113174
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivingheterozygous C57BL/6 males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • small uterus / IMPC
  • embryonic growth retardation / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased lymphocyte cell number / IMPC
  • abnormal hindbrain development / IMPC
  • abnormal midbrain development / IMPC
  • short tibia / IMPC
  • abnormal forebrain development / IMPC
  • abnormal embryo size / IMPC
  • male infertility / IMPC
  • follicular atresia / IMPC
  • dysplasia / IMPC
  • abnormal optic disk morphology / IMPC
  • female infertility / IMPC
  • abnormal neural tube closure / IMPC
  • absent seminal vesicle / IMPC
  • spermatogenesis defect / IMPC
  • decreased body length / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal leukocyte cell number / MGI
  • abnormal erythropoiesis / MGI
  • increased bone marrow cell number / MGI
  • abnormal liver physiology / MGI
  • abnormal ovary morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • small seminiferous tubules / MGI
  • small seminal vesicle / MGI
  • thick dermal layer / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal cornea morphology / MGI
  • abnormal circulating alanine transaminase level / MGI
  • anemia / MGI
  • postnatal growth retardation / MGI
  • abnormal pituitary secretion / MGI
  • abnormal homeostasis / MGI
  • liver inflammation / MGI
  • decreased inflammatory response / MGI
  • abnormal reproductive system physiology / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal ovulation / MGI
  • neoplasm / MGI
  • increased T cell derived lymphoma incidence / MGI
  • increased skin papilloma incidence / MGI
  • abnormal vision / MGI
  • abnormal eye morphology / MGI
  • abnormal sexual interaction / MGI
  • small uterus / MGI
  • oligozoospermia / MGI
  • abnormal eye size / MGI
  • small prostate gland / MGI
  • decreased circulating testosterone level / MGI
  • abnormal long term object recognition memory / MGI
  • delayed wound healing / MGI
  • cardiac fibrosis / MGI
  • thrombocytopenia / MGI
  • pulmonary interstitial fibrosis / MGI
  • nervous system phenotype / MGI
  • abnormal microglial cell physiology / MGI
  • abnormal mitosis / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased mitotic index / MGI
  • abnormal hematopoietic stem cell morphology / MGI
  • abnormal liver size / MGI
  • decreased testis weight / MGI
  • abnormal vascular wound healing / MGI
  • abnormal endometrium morphology / MGI
  • decreased uterus weight / MGI
  • increased spleen weight / MGI
  • increased osteoclast cell number / MGI
  • increased lymphocyte cell number / MGI
  • abnormal neutrophil morphology / MGI
  • decreased luteinizing hormone level / MGI
  • decreased growth hormone level / MGI
  • abnormal response to injury / MGI
  • abnormal circulating progesterone level / MGI
  • liver/biliary system phenotype / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • decreased liver regeneration / MGI
  • Leydig cell hypoplasia / MGI
  • decreased aggression / MGI
  • pulmonary fibrosis / MGI
  • decreased cerebral infarction size / MGI
  • abnormal leukocyte morphology / MGI
  • decreased somatotroph cell number / MGI
  • adenohypophysis hypoplasia / MGI
  • abnormal circulating tumor necrosis factor level / MGI
  • abnormal tumor necrosis factor level / MGI
  • abnormal physiological response to xenobiotic / MGI
  • absent estrous cycle / MGI
  • increased liver triglyceride level / MGI
  • enlarged eye anterior chamber / MGI
  • decreased tumor latency / MGI
  • Leydig cell atrophy / MGI

Literature references

  • The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.;Lemaire P, Vesque C, Schmitt J, Stunnenberg H, Frank R, Charnay P, ;1990;Molecular and cellular biology;10;3456-67; 2113174

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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