B6(Cg)-Chd8tm1.1Mabn/H

Status

Available to order

EMMA IDEM:11901
Citation informationRRID:IMSR_EM:11901 

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International strain nameB6(Cg)-Chd8tm1.1Mabn/H
Alternative nameChd8tm1.1Mabn
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolChd8tm1.1Mabn
Gene/Transgene symbolChd8

Information from provider

ProviderMichiel Basson
Provider affiliationCCRB, King's College London
Genetic informationConditional Chd8 allele, exon 3 flanked by loxP sites.
Phenotypic informationHomozygous:
No phenotype

Heterozygous:
No phenotype
Breeding historyGenerated in C57BL/6 ES cells, crossed to Flpe and b-actin cre deleter strains (each backcrossed 3 generations on C57BL/6J), then backcrossed 3-5 generations and intercrossed.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • hyperplasia / IMPC
  • decreased locomotor activity / IMPC
  • lymphoid hyperplasia / IMPC
  • increased lymphocyte cell number / IMPC
  • impaired glucose tolerance / IMPC
  • embryonic lethality prior to organogenesis / IMPC
MGI phenotypes (gene matching)
  • megacephaly / MGI
  • abnormal social investigation / MGI
  • increased anxiety-related response / MGI
  • decreased startle reflex / MGI
  • absent mesoderm / MGI
  • failure of primitive streak formation / MGI
  • embryonic growth arrest / MGI
  • increased brain weight / MGI
  • abnormal inner cell mass morphology / MGI
  • abnormal nervous system development / MGI
  • increased ectoderm apoptosis / MGI
  • inner cell mass degeneration / MGI
  • abnormal intestinal transit time / MGI
  • increased prepulse inhibition / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • impaired learning / MGI
  • decreased intestine length / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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