IMPC phenotypes (gene matching)
B6(Cg)-Zranb1tm(G11Del)/H
| Status | Available to order |
| EMMA ID | EM:11902 |
| Citation information | RRID:IMSR_EM:11902 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6(Cg)-Zranb1tm(G11Del)/H |
| Alternative name | ZranG11Del |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Zranb1G11Del |
| Gene/Transgene symbol | Zranb1 |
Information from provider
| Provider | Julius Mieszczanek |
| Provider affiliation | PNAC, MRC Laboratory of Molecular Biology |
| Genetic information | An insertion of the lacZ-PGK-neomycin resistance cassette in the second intron and a deletion in the third exon. |
| Phenotypic information | Homozygous:Homozygous mice are weaned runty but survive when kept on the high nutrient diet; both males and females are sterile.Heterozygous:No phenotype. |
| Breeding history | Strain was kept by crossing heterozygous animals for 40 generations. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- immune system phenotype / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased T helper 1 cell number / MGI
- decreased circulating interferon-gamma level / MGI
- decreased circulating interleukin-17 level / MGI
- decreased T-helper 17 cell number / MGI
Literature references
- The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.;Harris Lee D, Le Pen Janic, Scholz Nico, Mieszczanek Juliusz, Vaughan Natalie, Davis Simon, Berridge Georgina, Kessler Benedikt M, Bienz Mariann, Licchesi Julien D F, ;2021;The Journal of biological chemistry;296;100246; 33853758
- NLRP3 inflammasome and hearing loss: from mechanisms to therapies.;Murillo-Cuesta Silvia, Seoane Elena, Cervantes Blanca, Zubeldia Jose Manuel, Varela-Nieto Isabel, ;2025;Journal of neuroinflammation;22;225; 41046290