B6.CBACa-Tg(CD2-Il5)5C1Ldt/H
| Status | Available to order |
| EMMA ID | EM:01191 |
| Citation information | RRID:IMSR_EM:01191 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.CBACa-Tg(CD2-Il5)5C1Ldt/H |
| Alternative name | CBA-TgN(IL5) 1 Glx |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD2-Il5)5C1Ldt |
| Gene/Transgene symbol | Tg(CD2-Il5)5C1Ldt |
Information from provider
| Provider | Colin J Sanderson |
| Provider affiliation | National Institute for Medical Research |
| Genetic information | CBA-TgN(IL5)1Glx mice have been engineered to over-express IL-5 in their T-cells using a genomic fragment containing Il5, coupled to the locus control region (LCR) from the CD2 T-cell surface antigen gene. The LCR region ensures constitutive expression of IL-5 from all T-cells. |
| Phenotypic information | The IL-5 mice are macroscopically normal apart from an enlarged spleen which contains numerous eosinophils at various stages of differentiation. Heterozygous mice have about 8 copies of the Il5 transgene and show a life-long blood and tissue eosinophilia. Homozygous mice have higher numbers of eosinophils than heterozygotes but are difficult to breed. |
| Breeding history | The line has been maintained for many generations on a C57BL/6J background. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Eosinophilia in transgenic mice expressing interleukin 5.;Dent L A, Strath M, Mellor A L, Sanderson C J, ;1990;The Journal of experimental medicine;172;1425-31; 2230651