MGI phenotypes (allele matching)
- decreased susceptibility to endotoxin shock / MGI
129S2;129P2-Gcatm1Roes/H
| Status | Available to order |
| EMMA ID | EM:01194 |
| Citation information | RRID:IMSR_EM:01194 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S2;129P2-Gcatm1Roes/H |
| Alternative name | Gca |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gcatm1Roes |
| Gene/Transgene symbol | Gca |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | Grancalcin, one of the penta-EF-hand Ca(2+) binding proteins, is expressed at high levels in polymorphonuclear granulocytes (neutrophils) and implicated in the regulation of neutrophil effector functions. To determine the role of grancalcin in vivo, the gene encoding grancalcin (Gca) has been inactivated in these mice. |
| Phenotypic information | The grancalcin (Gca) gene has been inactivated to generate grancalcin-deficient mice. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased susceptibility to endotoxin shock / MGI
Literature references
- Granulocyte function in grancalcin-deficient mice.;Roes Jürgen, Choi B Ken, Power David, Xu Ping, Segal Anthony W, ;2003;Molecular and cellular biology;23;826-30; 12529388