STOCK Ret^tm1Kln/H

Status	Available to order
EMMA ID	EM:11959
Citation information	RRID:IMSR_EM:11959 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Ret^tm1Kln/H
Alternative name	(C57BL/6J x 129) Ret tm1EKra
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Ret^tm1Kln
Gene/Transgene symbol	Ret

Information from provider

Provider	Edgar Kramer
Provider affiliation	Biomedical Research, School of Medicine, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth
Genetic information	loxP sites were introduced surrounding exon 12 of the tyrosine-protein kinase receptor Ret by homologous recombination.
Phenotypic information	Homozygous: no obvious phenotype so far found Heterozygous: no obvious phenotype so far found
Breeding history	The mice were kept on a C57BL/6J genetic background with contributions of 129/Sv and CBA/J from the embryonic stem cells and different Flpe and cre mouse lines.
References	Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.;Kramer Edgar R, Knott Laura, Su Fengyun, Dessaud Eric, Krull Catherine E, Helmbacher Françoise, Klein Rüdiger, ;2006;Neuron;50;35-47; 16600854 RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.;Kowsky Sebastian, Pöppelmeyer Charlotte, Kramer Edgar R, Falkenburger Björn H, Kruse Anja, Klein Rüdiger, Schulz Jörg B, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20049-54; 18056810 Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.;Aron Liviu, Klein Pontus, Pham Thu-Trang, Kramer Edgar R, Wurst Wolfgang, Klein Rüdiger, ;2010;PLoS biology;8;e1000349; 20386724 Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.;Gonzalez-Reyes Luis E, Verbitsky Miguel, Blesa Javier, Jackson-Lewis Vernice, Paredes Daniel, Tillack Karsten, Phani Sudarshan, Kramer Edgar R, Przedborski Serge, Kottmann Andreas H, ;2012;Neuron;75;306-19; 22841315 Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.;Meka Durga Praveen, Müller-Rischart Anne Kathrin, Nidadavolu Prakash, Mohammadi Behnam, Motori Elisa, Ponna Srinivas Kumar, Aboutalebi Helia, Bassal Mahmoud, Annamneedi Anil, Finckh Barbara, Miesbauer Margit, Rotermund Natalie, Lohr Christian, Tatzelt Jörg, Winklhofer Konstanze F, Kramer Edgar R, ;2015;The Journal of clinical investigation;125;1873-85; 25822020 Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.;Drinkut Anja, Tillack Karsten, Meka Durga P, Schulz Jorg B, Kügler Sebastian, Kramer Edgar R, ;2016;Cell death & disease;7;e2359; 27607574
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Renal agenesis, bilateral / Orphanet_1848
Multiple endocrine neoplasia type 2B / Orphanet_247709
Familial medullary thyroid carcinoma / Orphanet_99361
Renal agenesis, unilateral / Orphanet_93100
Haddad syndrome / Orphanet_99803
Multiple endocrine neoplasia type 2A / Orphanet_247698
Hirschsprung disease / Orphanet_388

MGI phenotypes (gene matching)

increased cell proliferation / MGI
abnormal large intestine morphology / MGI
abnormal colon morphology / MGI
abnormal small intestine morphology / MGI
hydronephrosis / MGI
absent kidney / MGI
abnormal kidney development / MGI
abnormal ureter morphology / MGI
abnormal urinary bladder morphology / MGI
abnormal adrenal gland morphology / MGI
abnormal thyroid gland morphology / MGI
decreased motor neuron number / MGI
abnormal motor neuron innervation pattern / MGI
abnormal sympathetic ganglion morphology / MGI
absent superior cervical ganglion / MGI
small superior cervical ganglion / MGI
abnormal stellate ganglion morphology / MGI
abnormal sympathetic neuron morphology / MGI
abnormal enteric nervous system morphology / MGI
abnormal enteric ganglia morphology / MGI
abnormal enteric neuron morphology / MGI
absent enteric neurons / MGI
abnormal innervation pattern to muscle / MGI
abnormal neuromuscular synapse morphology / MGI
seminiferous tubule degeneration / MGI
arrest of spermatogenesis / MGI
abnormal spermatogenesis / MGI
abnormal lung development / MGI
decreased body weight / MGI
distended abdomen / MGI
postnatal growth retardation / MGI
male infertility / MGI
neoplasm / MGI
increased pheochromocytoma incidence / MGI
neonatal lethality / MGI
premature death / MGI
abnormal kidney morphology / MGI
no abnormal phenotype detected / MGI
abnormal innervation / MGI
muscular atrophy / MGI
cryptorchism / MGI
dilated renal tubules / MGI
abnormal vas deferens morphology / MGI
abnormal neuron morphology / MGI
aganglionic megacolon / MGI
small kidney / MGI
no phenotypic analysis / MGI
abnormal gastrocnemius morphology / MGI
increased neuron apoptosis / MGI
decreased neuron apoptosis / MGI
abnormal intestinal peristalsis / MGI
intestinal hypoperistalsis / MGI
abnormal hypaxial muscle morphology / MGI
renal hypoplasia / MGI
increased thyroid adenoma incidence / MGI
thyroid gland hyperplasia / MGI
large ureter / MGI
dilated ureter / MGI
ureter obstruction / MGI
ureter stenosis / MGI
ectopic kidney / MGI
single kidney / MGI
abnormal kidney medulla development / MGI
nervous system phenotype / MGI
dilated renal glomerular capsule / MGI
abnormal ureter development / MGI
kidney cysts / MGI
abnormal cardiac ganglion morphology / MGI
absent ureter / MGI
abnormal submandibular gland morphology / MGI
abnormal defecation / MGI
abnormal feces composition / MGI
decreased kidney weight / MGI
abnormal muscle spindle morphology / MGI
decreased renal glomerulus number / MGI
abnormal kidney collecting duct morphology / MGI
impaired branching involved in ureteric bud morphogenesis / MGI
kidney atrophy / MGI
glomerulosclerosis / MGI
abnormal renal glomerulus morphology / MGI
renal/urinary system phenotype / MGI
endocrine/exocrine gland phenotype / MGI
digestive/alimentary phenotype / MGI
cardiovascular system phenotype / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI
abnormal neurotransmitter secretion / MGI
abnormal enzyme/coenzyme activity / MGI
abnormal ureteric bud morphology / MGI
abnormal adrenal medulla morphology / MGI
adrenergic chromaffin cell hyperplasia / MGI
adrenal cortical hyperplasia / MGI
abnormal sympathetic postganglionic fiber morphology / MGI
abnormal parasympathetic postganglionic fiber morphology / MGI
abnormal pterygopalatine ganglion morphology / MGI
abnormal prevertebral ganglion morphology / MGI
abnormal mesonephros morphology / MGI
distended ileum / MGI
absent kidney cortex / MGI
abnormal neuron differentiation / MGI
increased ganglioneuroma incidence / MGI
mortality/aging / MGI
ectopic ureteric bud / MGI
abnormal branching involved in ureteric bud morphogenesis / MGI
abnormal ureteric bud elongation / MGI
abnormal ureteric bud invasion / MGI
abnormal metanephric mesenchyme morphology / MGI
abnormal kidney mesenchyme morphology / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, complete penetrance / MGI
preweaning lethality, incomplete penetrance / MGI
increased kidney apoptosis / MGI
increased metanephric mesenchyme apoptosis / MGI
renal cast / MGI
absent nephrogenic zone / MGI
ectopic testis / MGI
absent kidney medulla / MGI
ectopic ovary / MGI
blind ureter / MGI
oligohydramnios / MGI
abnormal enteric neural crest cell morphology / MGI
absent enteric neural crest cell / MGI
abnormal enteric neural crest cell migration / MGI

Literature references

Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.;Kramer Edgar R, Knott Laura, Su Fengyun, Dessaud Eric, Krull Catherine E, Helmbacher Françoise, Klein Rüdiger, ;2006;Neuron;50;35-47; 16600854
RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.;Kowsky Sebastian, Pöppelmeyer Charlotte, Kramer Edgar R, Falkenburger Björn H, Kruse Anja, Klein Rüdiger, Schulz Jörg B, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20049-54; 18056810
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.;Aron Liviu, Klein Pontus, Pham Thu-Trang, Kramer Edgar R, Wurst Wolfgang, Klein Rüdiger, ;2010;PLoS biology;8;e1000349; 20386724
Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.;Gonzalez-Reyes Luis E, Verbitsky Miguel, Blesa Javier, Jackson-Lewis Vernice, Paredes Daniel, Tillack Karsten, Phani Sudarshan, Kramer Edgar R, Przedborski Serge, Kottmann Andreas H, ;2012;Neuron;75;306-19; 22841315
Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration.;Meka Durga Praveen, Müller-Rischart Anne Kathrin, Nidadavolu Prakash, Mohammadi Behnam, Motori Elisa, Ponna Srinivas Kumar, Aboutalebi Helia, Bassal Mahmoud, Annamneedi Anil, Finckh Barbara, Miesbauer Margit, Rotermund Natalie, Lohr Christian, Tatzelt Jörg, Winklhofer Konstanze F, Kramer Edgar R, ;2015;The Journal of clinical investigation;125;1873-85; 25822020
Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.;Drinkut Anja, Tillack Karsten, Meka Durga P, Schulz Jorg B, Kügler Sebastian, Kramer Edgar R, ;2016;Cell death & disease;7;e2359; 27607574

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STOCK Rettm1Kln/H