IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
STOCK Vkorc1Y139C/H
| Status | Available to order |
| EMMA ID | EM:11995 |
| Citation information | RRID:IMSR_EM:11995 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Vkorc1Y139C/H |
| Alternative name | HM_Y139C |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Vkorc1Y139C |
| Gene/Transgene symbol | Vkorc1 |
Information from provider
| Provider | Colin Prescott |
| Provider affiliation | Biological Sciences, University of Reading |
| Genetic information | House mouse homozygous for the Vkorc1 mutation Y139C. |
| Phenotypic information | Homozygous:This mutation confers a degree of resistance to anticoagulants, and in particular to the rodenticide anticoagulants.Heterozygous:The degree of resistance is greater for homozygous animals than for heterozygous animals. |
| Breeding history | Wild-derived house mice that possessed the Vkorc1 mutation Y139C were crossed with albino Swiss CD-1 house mice. The Y139C mutation was then transferred for six generations onto the albino Swiss CD-1 house mouse background, and then backcrossed to produce the homozygous strain. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary combined deficiency of vitamin K-dependent clotting factors / Orphanet_98434
MGI phenotypes (gene matching)
Literature references
- The genetic basis of resistance to anticoagulants in rodents.;Pelz Hans-Joachim, Rost Simone, Hünerberg Mirja, Fregin Andreas, Heiberg Ann-Charlotte, Baert Kristof, MacNicoll Alan D, Prescott Colin V, Walker Anne-Sophie, Oldenburg Johannes, Müller Clemens R, ;2005;Genetics;170;1839-47; 15879509