C57BL/6-Tg(KRT5-Cxcl13)F12Rlep/Orl
| Status | Available to order |
| EMMA ID | EM:11996 |
| Citation information | RRID:IMSR_EM:11996 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(KRT5-Cxcl13)F12Rlep/Orl |
| Alternative name | K5-CXCL13-F12 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT5-Cxcl13)F12Rlep |
| Gene/Transgene symbol | Tg(KRT5-Cxcl13)F12Rlep |
Information from provider
| Provider | Rozen Le Panse |
| Provider affiliation | Centre de Recherche en Myologie, UMRS 974 - Sorbonne Université/INSERM |
| Genetic information | Transgenic mice with the mouse Cxcl13 (C-X-C motif chemokine ligand 13) transgene expressed in all keratin 5-positive epithelial cells. |
| Phenotypic information | Homozygous:Homozygous mice did not exhibit a particular phenotype and appeared similar to wild-type (WT) mice, as they grew up and bred as WT mice. They overexpressed Cxcl13 in keratin 5-positive cells. It should be noted that they did not show evident motor impairment compared to WT mice but had less muscle strength. All details are published in Weiss et al., Oncotarget, Vol. 7, No. 7, 2016.Heterozygous:Heterozygous mice have not been fully investigated. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Literature references
- Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis.;Weiss Julia Miriam, Robinet Marieke, Aricha Revital, Cufi Perrine, Villeret Bérengère, Lantner Frida, Shachar Idit, Fuchs Sara, Souroujon Miriam C, Berrih-Aknin Sonia, Le Panse Rozen, ;2016;Oncotarget;7;7550-62; 26771137