IMPC phenotypes (gene matching)
C;129P2-Lbptm1Jack/Orl
| Status | Available to order |
| EMMA ID | EM:00122 |
| Citation information | RRID:IMSR_EM:00122 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C;129P2-Lbptm1Jack/Orl |
| Alternative name | LBP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lbptm1Jack |
| Gene/Transgene symbol | Lbp |
Information from provider
| Provider | B Ryffel |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | The mice are generated by a deletion in the first exon of the lipopolysaccharide (LPS) binding protein (Lbp) gene; the first exon include the start site and part of the first intron of 14 kb. |
| Phenotypic information | The Lbp homozygous mice are viable and fertile. In vitro experiments using whole blood demonstrate a failure to respond to LPS, whereas in vivo no significant differences in plasma levels of tumor necrosis factor alpha are observed. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased susceptibility to bacterial infection / MGI
MGI phenotypes (gene matching)
- abnormal liver physiology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal innate immunity / MGI
- abnormal neutrophil physiology / MGI
- abnormal acute inflammation / MGI
- abnormal immune serum protein physiology / MGI
- abnormal nitric oxide homeostasis / MGI
- decreased susceptibility to injury / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- abnormal tumor necrosis factor secretion / MGI
- decreased tumor necrosis factor secretion / MGI
- abnormal chemokine level / MGI
- abnormal blood homeostasis / MGI
Literature references
- Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection.;Jack R S, Fan X, Bernheiden M, Rune G, Ehlers M, Weber A, Kirsch G, Mentel R, Fürll B, Freudenberg M, Schmitz G, Stelter F, Schütt C, ;1997;Nature;389;742-5; 9338787