MGI phenotypes (allele matching)
B6.129S2-Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Orl
| Status | Available to order |
| EMMA ID | EM:01236 |
| Citation information | RRID:IMSR_EM:01236 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu/Orl |
| Alternative name | TgH13(d11lac)+ |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Evx2/Hoxd13tm5.1(Hoxd11/lacZ)Ddu |
| Gene/Transgene symbol | Evx2 |
Information from provider
| Provider | Duboule Denis |
| Provider affiliation | Laboratoire Moléculaire et Morphogenèse |
| Genetic information | Insertion of a transgene in the middle of the Evx2/Hoxd13 intergenic region. Insertion of a fusion gene derived from Hoxd11 and lacZ and of a loxP-flanked PGK-neo selection cassette. After that, excision of the cassette by the action of cre recombinase. |
| Phenotypic information | Digits II and V short, radius and ulna short and abnormal in shapes, malformation of wrist and lateral deflections of the hand. |
| Breeding history | Backcross: N10, Intercross: N10. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- short limbs / MGI
- abnormal forelimb morphology / MGI
- abnormal carpal bone morphology / MGI
- decreased body weight / MGI
- male infertility / MGI
- abnormal digit morphology / MGI
- brachyphalangia / MGI
- brachydactyly / MGI
- abnormal metacarpal bone morphology / MGI
- short radius / MGI
- short ulna / MGI
- bowed ulna / MGI
- bowed radius / MGI
- short metacarpal bones / MGI
- abnormal phalanx morphology / MGI
Literature references
- A calcium and free fatty acid-modulated protein kinase as putative effector of the fusicoccin 14-3-3 receptor.;van der Hoeven P C, Siderius M, Korthout H A, Drabkin A V, de Boer A H, ;1996;Plant physiology;111;857-65; 8754686