FVB-Tg(CEPHY152F7)57Hgc/Orl

Status	Available to order
EMMA ID	EM:01238
Citation information	RRID:IMSR_EM:01238 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB-Tg(CEPHY152F7)57Hgc/Orl
Alternative name	YAC Lg 57
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(CEPHY152F7)57Hgc
Gene/Transgene symbol	Tg(CEPHY152F7)57Hgc

Information from provider

Provider	Edward Rubin
Provider affiliation	Laurence Berkeley National Laboratory, Human Genome Center - 1, cyclotron Road, Berkeley, CA 94720,
Genetic information	Mouse line transgenic for a YAC carrying a fragment of human chromosome 21 containing gene KCNJ6 (GIRK2 or KIR3.2). There are two copies of the transgene and only the males are transgenic.
Phenotypic information	Trisomy 21.
References	Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.;Smith D J, Zhu Y, Zhang J, Cheng J F, Rubin E M, ;1995;Genomics;27;425-34; 7558023

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous FVB males, wild-type females
Breeding at archiving centre	The transgene is on the Y chromosome. Method used for the sperm freezing: Ferti-Up with CARD. Used males were hemizygous.
Stage of embryos	2-cell

Literature references

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.;Smith D J, Zhu Y, Zhang J, Cheng J F, Rubin E M, ;1995;Genomics;27;425-34; 7558023
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.;Laguna Ariadna, Aranda Sergi, Barallobre María José, Barhoum Rima, Fernández Eduardo, Fotaki Vassiliki, Delabar Jean Maurice, de la Luna Susana, de la Villa Pedro, Arbonés Maria L, ;2008;Developmental cell;15;841-53; 19081073
Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice.;Roubertoux Pierre L, Baril Nathalie, Cau Pierre, Scajola Christophe, Ghata Adeline, Bartoli Catherine, Bourgeois Patrice, Christofaro Julie di, Tordjman Sylvie, Carlier Michèle, ;2017;Behavior genetics;47;305-322; 28204906

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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