STOCK Lama3tm1Arte/Ieg
| Status | Available to order |
| EMMA ID | EM:12384 |
| Citation information | RRID:IMSR_EM:12384 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Lama3tm1Arte/Ieg |
| Alternative name | Lama3 floxed |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lama3tm1Arte |
| Gene/Transgene symbol | Lama3 |
Information from provider
| Provider | Monique Aumailley |
| Provider affiliation | Biochemistry, Medical Faculty, University of Cologne |
| Genetic information | The gene coding for the laminin alpha3 chain has been floxed introducing loxP sites around exons 50 to 53. Allele symbol: Lama3tm1Arte; synonym used in publication: Lama3 floxed. Publication: Targeted Disruption of the Lama3 Gene in Adult Mice Is Sufficient to Induce Skin Inflammation and Fibrosis (http://www.informatics.jax.org/reference/summary?id=j:240054). |
| Phenotypic information | Homozygous:No phenotype. Mouse line with a floxed Lama3 gene that can be crossed for example with K14Cre ERT and be induced by tamoxifen.Heterozygous:no phenotype |
| Breeding history | The floxed mice were generated by ARTEMIS Pharmaceuticals GmbH (Cologne, Germany). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial isolated dilated cardiomyopathy / Orphanet_154
- LOC syndrome / Orphanet_2407
- Junctional epidermolysis bullosa, generalized intermediate / Orphanet_79402
- Junctional epidermolysis bullosa, generalized severe / Orphanet_79404
Literature references
- Targeted Disruption of the Lama3 Gene in Adult Mice Is Sufficient to Induce Skin Inflammation and Fibrosis.;Pesch Monika, König Sabrina, Aumailley Monique, ;2017;The Journal of investigative dermatology;137;332-340; 27729280