MGI phenotypes (allele matching)
B6;129S4-Rhogtm1Tnr/H
| Status | Available to order |
| EMMA ID | EM:01244 |
| Citation information | RRID:IMSR_EM:01244 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S4-Rhogtm1Tnr/H |
| Alternative name | Arhg |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rhogtm1Tnr |
| Gene/Transgene symbol | Rhog |
Information from provider
| Provider | Martin Turner |
| Provider affiliation | Babraham Institute |
| Genetic information | Knock-out line produced by homologous recombination of ES cells and injection into C57BL/6 blastocysts. Mice display defects in B-lymphocyte development. |
| Phenotypic information | Impairment of B-lymphocyte development. Mild hyper-reactivity of lymphocytes to antigen receptor engagement has been observed. |
| Breeding history | Strain of origin: 129S4/SvJae. The RhoG mice G1s (129 x C57BL/6) generated from the ES cell injection were intercrossed directly to produce the mouse line. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Immunological function in mice lacking the Rac-related GTPase RhoG.;Vigorito Elena, Bell Sarah, Hebeis Barbara J, Reynolds Helen, McAdam Simon, Emson Piers C, McKenzie Andrew, Turner Martin, ;2004;Molecular and cellular biology;24;719-29; 14701744